Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 15 findings · 3 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 5 · 33.3%Low 7 · 46.7%Moderate 3 · 20%High 0 · 0%

IUI in a stimulated cycle vs TI

Live birth rate per couple · couples with male subfertility

IUI in stimulated cycles showed no clear difference in live birth rate per couple (all cycles) compared with TI (low certainty).

2 findings from 1 review

IUI in a stimulated cycle vs TI or expectant management

Live birth rate per couple · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in live birth rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (low certainty).

2 findings from 1 review

IUI in a stimulated cycle vs TI or expectant management

Live birth rate per couple (all cycles)‐ clomiphene citrate or letrozole · participants with unexplained subfertility

IUI in a stimulated cycle probably leads to higher live birth rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (moderate certainty).

1 finding from 1 review

Gonadotropins with GnRH antagonist vs gonadotropins alone

Live birth rate per couple · intrauterine insemination (IUI) in women with infertility

It is very uncertain whether gonadotropins with GnRH antagonist changes live birth rate per couple compared with gonadotropins alone (very low certainty).

1 finding from 1 review

Aromatase inhibitors with gonadotropins vs anti‐oestrogens with gonadotropins

Live birth rate per couple · intrauterine insemination (IUI) in women with infertility

It is very uncertain whether aromatase inhibitors with gonadotropins changes live birth rate per couple compared with anti‐oestrogens with gonadotropins (very low certainty).

1 finding from 1 review