Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

19 questions · 19 findings · 9 reviews · Pregnancy and Childbirth

No studies found 1 · 5.3%GRADE not reported 1 · 5.3%Very low 5 · 26.3%Low 6 · 31.6%Moderate 5 · 26.3%High 1 · 5.3%

Dexamethasone: oral vs intramuscular – fetal/neonatal outcomes

Intraventricular haemorrhage · women at risk of preterm birth

It is very uncertain whether dexamethasone: oral changes intraventricular haemorrhage compared with intramuscular – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Betamethasone acetate plus phosphate vs betamethasone phosphate – fetal/neonatal outcomes

Intraventricular haemorrhage · women at risk of preterm birth

It is very uncertain whether betamethasone acetate plus phosphate changes intraventricular haemorrhage compared with betamethasone phosphate – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Betamethasone 12‐hourly vs 24‐hourly dosing – fetal/neonatal outcomes

Intraventricular haemorrhage · women at risk of preterm birth

It is very uncertain whether betamethasone 12‐hourly changes intraventricular haemorrhage compared with 24‐hourly dosing – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Intraventricular haemorrhage · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact showed no clear difference in intraventricular haemorrhage (IVH, all grades) compared with ECC (low certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs UCM

Intraventricular haemorrhage · babies born preterm, and their mothers

It is very uncertain whether DCC with immediate neonatal care after cord clamping changes intraventricular haemorrhage (IVH, all grades) compared with UCM (very low certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs ECC (subgroup analysis by gestation)

Intraventricular haemorrhage · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping leads to lower intraventricular haemorrhage (IVH, all grades) compared with ECC (subgroup analysis by gestation) (high certainty).

1 finding from 1 review

DCC with immediate neonatal care with cord intact vs ECC

Severe intraventricular haemorrhage · babies born preterm, and their mothers

DCC with immediate neonatal care with cord intact showed no clear difference in severe intraventricular haemorrhage (IVH grades 3, 4) compared with ECC (low certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs UCM

Severe intraventricular haemorrhage · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping showed no clear difference in severe intraventricular haemorrhage (IVH grades 3, 4) compared with UCM (low certainty).

1 finding from 1 review

DCC with immediate neonatal care after cord clamping vs ECC (subgroup analysis by gestation)

Severe intraventricular haemorrhage · babies born preterm, and their mothers

DCC with immediate neonatal care after cord clamping showed no clear difference in severe intraventricular haemorrhage (IVH grades 3, 4) compared with ECC (subgroup analysis by gestation) (low certainty).

1 finding from 1 review

Interventionist care vs expectant care

Intraventricular haemorrhage or hypoxic ischaemic encephalopathy · women with severe pre‐eclampsia between 24 and 34 weeks' gestation

Interventionist care probably leads to higher intraventricular haemorrhage or hypoxic ischaemic encephalopathy compared with expectant (delayed delivery) care (moderate certainty).

1 finding from 1 review

Corticosteroids vs placebo or no treatment

Intraventricular haemorrhage · infants born of women at risk of preterm birth

Neonatal and child outcomes: corticosteroids probably leads to lower intraventricular haemorrhage (IVH)№ of participants: 8475(12 RCTs) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Intraventricular haemorrhage, Papile grade 3/4 · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate probably leads to lower severe intraventricular haemorrhage (grade 3 or 4) (newborn/infant)** compared with placebo (outcomes (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

Intraventricular haemorrhage, Papile grade 3/4 · the fetus/neonate/infant

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid showed no clear difference in A9: Severe intraventricular haemorrhage (grade 3 or 4) – all fetuses… compared with single course (moderate certainty).

1 finding from 1 review

Amnioinfusion vs no amnioinfusion

Perinatal death or severe morbidity · pregnant women with confirmed or suspected chorioamnionitis

The review found no eligible studies for this question.

1 finding from 1 review

Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage

Serious neonatal morbidity

It is very uncertain whether cervical cerclage in combination with antibiotics and tocolytics changes serious neonatal morbidity (Reported in Miller 2014 as 'composite… compared with cervical cerclage alone (very low certainty).

1 finding from 1 review