Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 13 findings · 10 reviews · Stroke

No studies found 2 · 15.4%GRADE not reported 0 · 0%Very low 1 · 7.7%Low 5 · 38.5%Moderate 2 · 15.4%High 3 · 23.1%

Summary of findings table ‐ Starting long‐term therapeutic dose oral anticoagulation vs avoiding anticoagulation

Intracranial haemorrhage · survivors of stroke due to intracerebral haemorrhage with atrial fibrillation

Summary of findings table ‐ Starting long‐term therapeutic dose oral… showed no clear difference in intracranial haemorrhage compared with avoiding anticoagulation (moderate certainty).

1 finding from 1 review

General anaesthesia vs non‐general anaesthesia

Intracranial haemorrhage · acute ischaemic stroke endovascular treatment (long‐term)

The review found no eligible studies for this question.

2 findings from 1 review

Intravenous thrombolytic treatment vs standard‐of‐care therapy

Symptomatic intracranial haemorrhage at · people with stroke upon awakening

Intravenous thrombolytic treatment showed no clear difference in symptomatic intracranial haemorrhage at compared with standard medical care (high certainty).

1 finding from 1 review

Percutaneous vascular interventions vs intravenous thrombolytic treatment

Symptomatic intracranial haemorrhage at

Percutaneous vascular interventions showed no clear difference in symptomatic intracranial haemorrhage within first 14 days compared with intravenous thrombolytic treatment (low certainty).

1 finding from 1 review

Antiplatelet drug vs control

Symptomatic intracranial haemorrhage during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes symptomatic intracranial haemorrhage during treatment period compared with control (very low certainty).

1 finding from 1 review

Anticoagulant vs control

Symptomatic intracranial haemorrhage during treatment period · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant probably leads to higher symptomatic intracranial haemorrhage during treatment period compared with control (moderate certainty).

1 finding from 1 review

Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin

Symptomatic intracranial haemorrhage/haemorrhagic transformation of the cerebral infarct during treatment period (range 6 days to 16 days)⁹ · acute ischaemic stroke

Low‐molecular‐weight heparins or heparinoids showed no clear difference in symptomatic intracranial haemorrhage/haemorrhagic transformation of… compared with unfractionated heparin (low certainty).

1 finding from 1 review