What do systematic reviews say?

Recombinant human thyrotropin‐aided radioiodine vs radioiodine

Recombinant human thyrotropin‐aided radioiodine probably leads to higher hypothyroidism compared with radioiodine (moderate certainty).

• Recombinant human thyrotropin (rhTSH)‐aided radioiodine treatment for non‐toxic multinodular goitre 2021 · Cochrane Headline outcomes only
  RR 2.53 [1.52, 4.2]
  6 studies · 321 participants
  Moderate

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Any supplement containing iodine showed no clear difference in maternal hypothyroidism ‐ pregnancy compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

• Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
  RR 1.9 [0.57, 6.38]
  1 study · 365 participants
  Low

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Any supplement containing iodine showed no clear difference in maternal hypothyroidism ‐ postpartum compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

• Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
  RR 0.44 [0.06, 3.42]
  3 studies · 540 participants
  Low

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

It is very uncertain whether any supplement containing iodine changes neonatal hypothyroidism or elevated TSH compared with same supplement without iodine or no treatment/placebo (child… (very low certainty).

• Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
  RR 0.58 [0.11, 3.12]
  1 study · 219 participants
  Very low

Intervention not reported

The review found no eligible studies for this question.

• Iodine fortification of foods and condiments, other than salt, for preventing iodine deficiency disorders 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Radioiodine therapy versus antithyroid medications for Graves' disease 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 104 participants
  Very low