Cochrane · systematic review · CD010622
Recombinant human thyrotropin (rhTSH)‐aided radioiodine treatment for non‐toxic multinodular goitre
Huo, Y, Xie, J, Chen, S, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Metabolic and Endocrine DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
1
Included studies
NR
No studies 1 · 16.7%Ungraded 0 · 0%Very low 2 · 33.3%Low 1 · 16.7%Moderate 2 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Recombinant human thyrotropin‐aided radioiodine compared with radioiodine for non‐toxic multinodular goitre
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Health‐related quality of life Recombinant human thyrotropin‐aided radioiodine vs radioiodine | no estimate extracted | 1 study · 85 participants | Very low Downgraded: imprecision |
Hypothyroidism Recombinant human thyrotropin‐aided radioiodine vs radioiodine | RR 2.53 [1.52, 4.2] | 6 studies · 321 participants | Moderate Downgraded: imprecision |
Adverse events Recombinant human thyrotropin‐aided radioiodine vs radioiodine | RR 1.24 [0.94, 1.63] | 6 studies · 321 participants | Low Downgraded: imprecision |
Thyroid volume Recombinant human thyrotropin‐aided radioiodine vs radioiodine | no estimate extracted | 6 studies · 268 participants | Moderate Downgraded: imprecision |
All‐cause mortality Recombinant human thyrotropin‐aided radioiodine vs radioiodine | no estimate extracted | 1 study · 28 participants | Very low Downgraded: imprecision |
Costs Recombinant human thyrotropin‐aided radioiodine vs radioiodine | no estimate extracted | NR | No studies |