Cochrane · systematic review · CD010734
Iodine fortification of foods and condiments, other than salt, for preventing iodine deficiency disorders
Santos, JAR, Christoforou, A, Trieu, K, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Public HealthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
18
current version
GRADE rated
10
No studies
8
Included studies
NR
No studies 8 · 44.4%Ungraded 0 · 0%Very low 8 · 44.4%Low 1 · 5.6%Moderate 1 · 5.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Iodine fortification of foods and condiments, other than salt, for preventing iodine deficiency disorders
Population: all populations, including pregnant women, from any country
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death (all‐cause) | no estimate extracted | NR | No studies |
Goitre prevalence (RCT) | no estimate extracted | 1 study · 1 participants | Very low Downgraded: risk of bias |
Goitre prevalence (non‐RCT) | OR 1.6 [0.6, 4.31] | 83 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Physical development measures (non‐RCT) | no estimate extracted | NR | No studies |
a. Weight | no estimate extracted | 83 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
b. Height assessment tool not reported | no estimate extracted | 83 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
c. Weight‐for‐age computed from weight and age values | no estimate extracted | 83 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
d. Height‐for‐age computed from height and age values | no estimate extracted | 83 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
e. Weight‐for‐height computed from weight and height values | no estimate extracted | 83 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Mental development | no estimate extracted | NR | No studies |
Cognitive function and motor skill development | no estimate extracted | NR | No studies |
Cretinism | no estimate extracted | NR | No studies |
Hypothyroidism | no estimate extracted | NR | No studies |
Adverse effects (RCT) | no estimate extracted | 1 study · 33 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Urinary iodine concentration (RCT) | no estimate extracted | 6 studies · 2032 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Urinary iodine concentration (non‐RCT) | no estimate extracted | 262 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Thyroid‐stimulating hormone concentration | no estimate extracted | NR | No studies |
Serum thyroglobulin concentration | no estimate extracted | NR | No studies |