What do systematic reviews say?

Breast feeding with supplemental feeds by other than bottle vs breast feeding with supplemental feeds by bottle (all trials)

• Avoidance of bottles during the establishment of breastfeeds in preterm infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 1004 participants
  Low

Targeted individualized vs standard non‐individualized fortification

• Individualized versus standard diet fortification for growth and development in preterm infants receiving human milk 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 75 participants
  Very low

Prebiotic vs no prebiotics

• Prebiotics for the prevention of hyperbilirubinaemia in neonates 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 78 participants
  Low

Stopping feeds vs continuing feeds during transfusion

• Stopping enteral feeds for prevention of transfusion‐associated necrotising enterocolitis in preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Oropharyngeal colostrum (OPC) vs No treatment or saline or water

• Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants 2018 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 293 participants
  Very low

Non‐nutritive sucking (NNS) vs no NNS

• Non‐nutritive sucking for increasing physiologic stability and nutrition in preterm infants 2016 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 501 participants
  Low

Co‐bedding vs separate care

• Co‐bedding in neonatal nursery for promoting growth and neurodevelopment in stable preterm twins 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 6 participants
  Very low

Intervention not reported

• Telemedicine for the support of parents of high‐risk newborn infants 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 56 participants
  Very low

Transfer from incubator to cot at lower vs higher body weight

• Transfer of preterm infants from incubator to open cot at lower versus higher body weight 2011 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 276 participants
  High

Restricted vs standard fluid management

• Fluid restriction in the management of transient tachypnea of the newborn 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 80 participants
  Very low

Sildenafil plus iNO vs placebo plus iNO

• Sildenafil for pulmonary hypertension in neonates 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 24 participants
  Low

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Pentoxifylline with antibiotics (any dose or duration) showed no clear difference in length of hospital stay (LOS) in days compared with placebo or no intervention (low certainty).

• Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 157 participants
  Low

Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin

The review found no eligible studies for this question.

• Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics

The review found no eligible studies for this question.

• Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found