Antibiotics vs no treatment or placebo on top of topical antibiotics
Hearing · people (of any age) with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Findings
What do systematic reviews say?
20 questions · 21 findings · 9 reviews · Headline outcomes only
No studies found 3 · 14.3%GRADE not reported 0 · 0%Very low 13 · 61.9%Low 4 · 19%Moderate 1 · 4.8%High 0 · 0%
Topical antibiotics with steroids vs topical antibiotics
Hearing · people (of any age) with chronic suppurative otitis media or ear discharge
2 findings from 1 review
- Topical antibiotics with steroids for chronic suppurative otitis media 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 135 participantsVery low
- Topical antibiotics with steroids for chronic suppurative otitis media 2020 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 419 participantsVery low
Antibiotics vs no treatment or placebo on top of topical antibiotics
Hearing ‐ unclear · people with CSOM; one study included patients of unknown age; one study included children with CSOM who had not responded to initial…
1 finding from 1 review
- no estimate extracted1 study · 38 participantsVery low
Topical antibiotics vs placebo/no treatment
Hearing · patients with mucopurulent otorrhoea
1 finding from 1 review
- no estimate extracted1 study · 35 participantsVery low
Topical antibiotics vs acetic acid
Hearing · chronic suppurative otitis media
1 finding from 1 review
- Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 107 participantsVery low
Antibiotics vs no treatment/placebo
Hearing · children with CSOM
1 finding from 1 review
- no estimate extracted1 study · 33 participantsVery low
Antibiotics vs no treatment
Hearing · children aged 6 months to 12 years with otitis media with effusion (OME)
1 finding from 1 review
- no estimate extractedStudies not reportedLow
Antibiotics vs placebo
Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)
It is very uncertain whether antibiotics changes hearing ‐ return to normal hearing (as complete improvement in… compared with placebo (very low certainty).
1 finding from 1 review
- Peto OR 9.59 [3.51, 26.18]Studies not reportedVery low
Topical quinolone vs povidone‐iodine
Hearing · chronic suppurative otitis media
1 finding from 1 review
- Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 40 participantsVery low
Topical antibiotics with steroids vs placebo/no treatment
Hearing · chronic suppurative otitis media
1 finding from 1 review
- Topical antibiotics with steroids for chronic suppurative otitis media 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 123 participantsVery low
Antibiotics vs no treatment or placebo on top of topical antiseptics
Hearing · schoolchildren with CSOM
1 finding from 1 review
- no estimate extracted1 study · 204 participantsVery low
Gastrointestinal adverse events in people taking macrolide antibiotics vs placebo
Hearing loss · any indication
Other adverse events in people taking macrolide antibiotics showed no clear difference in hearing loss compared with placebo (low certainty).
1 finding from 1 review
- Adverse events in people taking macrolide antibiotics versus placebo for any indication 2019 · Cochrane Headline outcomes onlyOR 1.3 [1, 1.7]4 studies · 1369 participantsLow
Topical quinolone vs boric acid
Average change in hearing from baseline · chronic suppurative otitis media
1 finding from 1 review
- Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 390 participantsLow
Topical quinolone vs intramuscular gentamicin
Hearing · adults with CSOM
1 finding from 1 review
- Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes onlyno estimate extracted1 study · 60 participantsVery low
Topical quinolone vs oral amoxicillin‐clavulanic acid combination
Hearing · adults with CSOM
1 finding from 1 review
- Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes onlyno estimate extracted1 study · 56 participantsVery low
Topical quinolone vs quinolones
Hearing · people (of any age) with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
- Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Intervention not reported
Hearing · CSOM, recurrence of CSOM or suppuration following mastoidectomy or tympanoplasty
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Quinolone vs aminoglycosides
Hearing · people (of any age) with CSOM
1 finding from 1 review
- no estimate extracted4 studies · 132 participantsVery low
Intervention not reported
Hearing loss · children and adults with acute bacterial meningitis
The intervention probably leads to lower hearing loss (moderate certainty).
1 finding from 1 review
- Osmotic therapies added to antibiotics for acute bacterial meningitis 2018 · Cochrane Headline outcomes onlyRR 0.64 [0.44, 0.93]5 studies · 922 participantsModerate
Different dosing regimens of aminoglycosides (daily vs 8 hourly)
Hearing impairment following treatment · children with acute pyelonephritis
Different dosing regimens of aminoglycosides (daily showed no clear difference in hearing impairment following treatment compared with 8 hourly) (low certainty).
1 finding from 1 review
- RR 2.83 [0.33, 24.56]3 studies · 271 participantsLow