Findings

What do systematic reviews say?

8 questions · 10 findings · 5 reviews · Headline outcomes only

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No studies found 2 · 20%GRADE not reported 0 · 0%Very low 1 · 10%Low 3 · 30%Moderate 4 · 40%High 0 · 0%

Preterm formula vs standard term formula

Head circumference (mm) · preterm infants after hospital discharge

2 findings from 1 review

Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 130 participants
Moderate
Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 160 participants
Moderate

LCPUFA supplemented formula vs control formula

Head circumference at 12 months (z scores) ‐ DHA and AA vs normal term formula · term infants

LCPUFA supplemented formula showed no clear difference in head circumference at 12 months (z scores) ‐ DHA and AA vs normal… compared with control formula (low certainty).

1 finding from 1 review

Long chain polyunsaturated fatty acid supplementation in infants born at term 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 464 participants
Low

Postdischarge formula vs standard term formula

Head circumference (mm) · preterm infants after hospital discharge

2 findings from 1 review

Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 523 participants
Moderate
Nutrient‐enriched formula versus standard formula for preterm infants following hospital discharge 2016 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 576 participants
Moderate

High MCT formula vs low MCT formula

Growth: head circumference (cm/week) · promoting short‐term growth of preterm infants

1 finding from 1 review

High versus low medium chain triglyceride content of formula for promoting short‐term growth of preterm infants 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 61 participants
Low

Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria)

Growth: head circumference (cm/week) · formula‐fed low birth weight infants

The review found no eligible studies for this question.

1 finding from 1 review

Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Very high protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

Growth: head circumference (cm/week) · formula‐fed low birth weight infants

The review found no eligible studies for this question.

1 finding from 1 review

Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

Growth: head circumference (cm/week) · formula‐fed low birth weight infants

1 finding from 1 review

Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Intervention not reported

Head circumference gain (mm/week) · preterm infants

1 finding from 1 review

Nutrient‐enriched formula versus standard formula for preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 399 participants
Low