Cochrane · systematic review · CD003959
Higher versus lower protein intake in formula‐fed low birth weight infants
Fenton, TR, Al-Wassia, H, Premji, SS, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
6
No studies
9
Included studies
NR
No studies 9 · 60%Ungraded 0 · 0%Very low 1 · 6.7%Low 3 · 20%Moderate 2 · 13.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
High protein compared to low protein intake (restricted to studies meeting all a priori inclusion criteria) in formula‐fed low birth weight infants
Population: formula‐fed low birth weight infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight gain (g/kg/d) High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria) | no estimate extracted | 5 studies · 114 participants | Low Downgraded: risk of bias, inconsistency |
Linear growth (cm/week) High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria) | no estimate extracted | 2 studies · 48 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Head circumference growth (cm/week) High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria) | no estimate extracted | 1 study · 18 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
IQ score and Bayley score at 18 months or later High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria) | no estimate extracted | NR | No studies |
Necrotizing enterocolitis High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria) | no estimate extracted | 2 studies · 46 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Very high protein compared to low protein intake (restricted to studies meeting all a priori inclusion criteria) in formula‐fed low birth weight infants
Population: formula‐fed low birth weight infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight gain Very high protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria) | no estimate extracted | NR | No studies |
Linear growth Very high protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria) | no estimate extracted | NR | No studies |
Head circumference growth Very high protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria) | no estimate extracted | NR | No studies |
IQ score and Bayley score at 18 months or later Very high protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria) | no estimate extracted | NR | No studies |
Necrotizing enterocolitis Very high protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria) | no estimate extracted | NR | No studies |
Very high protein compared to high protein intake (restricted to studies meeting all a priori inclusion criteria) in formula‐fed low birth weight infants
Population: formula‐fed low birth weight infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Weight gain (g/d) to discharge Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria) | no estimate extracted | 1 study · 77 participants | Moderate Downgraded: imprecision |
Linear growth (cm/week) Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria) | no estimate extracted | 1 study · 77 participants | Moderate Downgraded: imprecision |
Head circumference growth Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria) | no estimate extracted | NR | No studies |
IQ score and Bayley score at 18 months or later Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria) | no estimate extracted | NR | No studies |
Necrotizing enterocolitis Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria) | no estimate extracted | NR | No studies |