What do systematic reviews say?

LABA/LAMA vs placebo

• Once daily long‐acting beta2‐agonists and long‐acting muscarinic antagonists in a combined inhaler versus placebo for… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 4952 participants
  High

Ravulizumab vs placebo or alternative treatment

• Interventions for atypical haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
  no estimate extracted
  44 participants
  Very low

Eculizumab vs placebo or alternative treatment

• Interventions for atypical haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
  no estimate extracted
  100 participants
  Very low

GLP‐1 agonists vs placebo

• GLP‐1 receptor agonists for Parkinson's disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 60 participants
  Low

Potassium binder vs placebo

• Potassium binders for chronic hyperkalaemia in people with chronic kidney disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 289 participants
  Very low

Clindamycin phosphate 1.2% + tretinoin 0.025% gel vs placebo

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 83 participants
  Moderate

Metronidazole vs placebo

The review found no eligible studies for this question.

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Tetracycline vs placebo

The review found no eligible studies for this question.

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Doxycycline 40 mg vs placebo

The review found no eligible studies for this question.

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Azelaic acid vs placebo

The review found no eligible studies for this question.

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical ivermectin vs placebo

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1371 participants
  High

Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment

• Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
  Katchooi 2018 (unclear risk of bias): light vibrational forces had no statistically significant (P>0.05) effect on OHRQoL when used with orthodontic aligners.
  1 study · 27 participants
  GRADE not reported

Atraumatic restorative treatment vs placebo

ART and placebo did not differ for oral health-related quality of life, based on an indirect network estimate with no direct trials (MD -0.01, 95% CI -0.40 to 0.38; ungraded).

• Silver diamine fluoride and oral health-related quality of life: A review and network meta-analysis. 2022 All outcomes

  Post-treatment · Pediatric dental care; trials conducted in China, the USA, and Brazil · Indirect network estimate (no direct trials)
  MD -0.01 [-0.40, 0.38]
  0 studies
  GRADE not reported

Probiotics vs placebo

• Probiotics for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 37 participants
  Low

Silver diamine fluoride (SDF) vs placebo

SDF did not significantly differ from placebo for oral health-related quality of life in children (MD 0.03, 95% CI -0.16 to 0.22; ungraded).

• Silver diamine fluoride and oral health-related quality of life: A review and network meta-analysis. 2022 All outcomes

  Post-treatment · Pediatric dental care; trials conducted in China, the USA, and Brazil
  MD 0.03 [-0.16, 0.22]
  2 studies · 440 participants
  GRADE not reported

Vitamin D vs placebo

• Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 37 participants
  Low

Silver diamine fluoride (SDF, including SDF + fluoride varnish) vs Other standard-of-care caries treatments pooled (placebo, ART, or ART + fluoride varnish)

SDF had no significant effect on oral health-related quality of life versus pooled standard-of-care caries treatments (SMD -0.06, 95% CI -0.20 to 0.08; ungraded).

• Silver diamine fluoride and oral health-related quality of life: A review and network meta-analysis. 2022 All outcomes

  Post-treatment (follow-up varied by trial) · Pediatric dental care; trials conducted in China, the USA, and Brazil
  SMD -0.06 [-0.20, 0.08]
  5 studies · 820 participants
  GRADE not reported

Aerobic exercise vs no exercise or placebo exercise

• Exercise training for adults undergoing maintenance dialysis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 306 participants
  Very low

Resistance training vs no exercise or placebo exercise

• Exercise training for adults undergoing maintenance dialysis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 176 participants
  Very low

Aerobic exercise and strength training vs no exercise or placebo exercise

• Exercise training for adults undergoing maintenance dialysis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 228 participants
  Very low