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Evidence found and GRADE certainty

8 questions · 8 findings · 5 reviews · Schizophrenia

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No studies found 0 · 0%GRADE not reported 4 · 50%Very low 2 · 25%Low 2 · 25%Moderate 0 · 0%High 0 · 0%

ASENAPINE vs placebo

Global state: No clinically important change (as defined by the original studies) · adults with schizophrenia

ASENAPINE may leads to lower global state: No clinically important change CGI‐I compared with PLACEBO (low certainty).

1 finding from 1 review

α‐FLUPENTHIXOL vs PLACEBO or β‐FLUPENTHIXOL

Global state: clinically important change in global state needing additional medication ‐ chlorpromazine · patients with schizophrenia

It is very uncertain whether α‐FLUPENTHIXOL changes global state: clinically important change in global state needing… compared with PLACEBO or β‐FLUPENTHIXOL (very low certainty).

1 finding from 1 review

Modafinil vs placebo

Global state: clinically important change in global state · schizophrenia or related disorders

It is very uncertain whether modafinil changes global state: clinically important change in global state compared with placebo (very low certainty).

1 finding from 1 review

WENDAN DECOCTION vs placebo or no treatment

Global state: Clinically important change ‐ no improvement ‐ defined as PANSS < 50% reduction (short term) · patients with schizophrenia

WENDAN DECOCTION may leads to lower global state: Clinically important change ‐ no improvement ‐ defined… compared with PLACEBO OR NO TREATMENT (low certainty).

1 finding from 1 review