What do systematic reviews say?

Educational intervention vs usual care or attention control

Educational interventions showed no clear difference in general fatigue (at the end of the educational intervention) compared with control (usual care or attention control) (low certainty).

• Educational interventions for the management of cancer‐related fatigue in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  12 studies · 1711 participants
  Low
• Educational interventions for the management of cancer‐related fatigue in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 1524 participants
  Moderate

Educational intervention vs usual care or attention control

Educational interventions showed no clear difference in fatigue distress (at the end of the educational intervention) compared with control (usual care or attention control) (low certainty).

• Educational interventions for the management of cancer‐related fatigue in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 622 participants
  Low

Educational intervention vs usual care or attention control

Educational interventions showed no clear difference in fatigue interference (at the end of the educational intervention) compared with control (usual care or attention control) (moderate certainty).

• Educational interventions for the management of cancer‐related fatigue in adults 2016 · Cochrane Headline outcomes only
  SMD 0.35
  4 studies · 439 participants
  Moderate

Multimodal intervention (exercise plus other interventions) plus usual care vs usual care

• Exercise for cancer cachexia in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 44 participants
  Very low

Imiquimod vs cidofovir

Summary of findings for imiquimod probably leads to higher fatigue ‐ any grade compared with cidofovir (moderate certainty).

• Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
  RR 1.25 [1.02, 1.55]
  1 study · 168 participants
  Moderate

Imiquimod vs cidofovir

The review found no eligible studies for this question.

• Medical interventions for high‐grade vulval intraepithelial neoplasia 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

CBT with therapist support vs fatigue information leaflet only

• Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 18 participants
  Very low
• Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 16 participants
  Very low

Physical exercise training vs usual care

• Physical exercise training interventions for children and young adults during and after treatment for childhood cancer 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 22 participants
  Very low
• Physical exercise training interventions for children and young adults during and after treatment for childhood cancer 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Non‐pharmacological interventions for fatigue in rheumatoid arthritis 2013 · Cochrane Headline outcomes only
  no estimate extracted
  13 studies · 1556 participants
  Low

Intervention not reported

• Non‐pharmacological interventions for fatigue in rheumatoid arthritis 2013 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 371 participants
  Moderate

Relaxation vs control

It is very uncertain whether summary of findings: relaxation changes fatigue PROMIS‐Fatigue Short Form 1.0 and Rhoten and Piper fatigue… compared with control (very low certainty).

• Interventions for improving sleep quality in people with chronic kidney disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 119 participants
  Very low

Intervention not reported

• Exercise interventions on health‐related quality of life for people with cancer during active treatment 2012 · Cochrane Headline outcomes only
  no estimate extracted
  23 studies · 1721 participants
  Very low

MX exercise training vs control

• Mixed exercise training for adults with fibromyalgia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 493 participants
  Moderate

Music intervention plus standard care vs usual care

• Music interventions for improving psychological and physical outcomes in people with cancer 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Music intervention plus standard care vs usual care

• Music interventions for improving psychological and physical outcomes in people with cancer 2021 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 498 participants
  Low

Intervention not reported

• Telephone interventions for symptom management in adults with cancer 2020 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 895 participants
  Very low

Electroacupuncture vs no treatment

• Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 27 participants
  Low

Physical activity advice plus omega 3 vs no physical activity advice plus omega 3

• Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 25 participants
  Very low
• Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 25 participants
  Very low
• Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 25 participants
  Very low

Physical activity advice plus placebo vs no physical activity advice plus placebo

• Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 27 participants
  Very low
• Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 27 participants
  Very low
• Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 27 participants
  Very low

Physical activity advice plus placebo vs no physical activity advice plus omega 3

• Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low
• Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low
• Interventions for fatigue in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low