evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

417 questions · 819 findings · 72 reviews

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 9 · 1.1%GRADE not reported 759 · 92.7%Very low 39 · 4.8%Low 5 · 0.6%Moderate 6 · 0.7%High 1 · 0.1%

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

In Australia, the pooled prevalence of primary-teeth caries in children was 28.5% (95% CI 20.3 to 38.5); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

In Africa, the pooled prevalence of primary-teeth caries in children was 53.1% (95% CI 44.3 to 61.7); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

In Asia, the pooled prevalence of primary-teeth caries in children was 52.6% (95% CI 46.7 to 58.5); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

In Europe, the pooled prevalence of primary-teeth caries in children was 21.4% (95% CI 15.3 to 29.1); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

In the Americas, the pooled prevalence of primary-teeth caries in children was 45.8% (95% CI 34.2 to 58.0); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

The pooled worldwide prevalence of dental caries in primary teeth in children was 46.2% (95% CI 41.6 to 50.8), with very high heterogeneity (I2=99.2%); certainty not graded.

1 finding from 1 review

HIV-infected children on antiretroviral therapy (HI) vs HIV-exposed but uninfected children (HEU)

Dental caries · Children and adolescents (<18 years) living with HIV (CLWH)

HIV-infected children on ART had higher odds of dental caries than HEU children in a cohort study (OR 2.88, 95% CI 1.71 to 4.84; ungraded).

2 findings from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs HIV-negative individuals

Dental caries · Children and adolescents (<18 years) living with HIV (CLWH)

In cross-sectional studies, children and adolescents with HIV on antiretroviral therapy had about twice the odds of dental caries versus HIV-negative peers (OR 2.04, 95% CI 1.21 to 3.42; very low certainty).

3 findings from 1 review

HAART (highly active antiretroviral therapy, >=3 drugs) vs HIV-positive not receiving HAART (standard ART or HAART-naive)

Dental caries · Children and adolescents (<18 years) living with HIV (CLWH)

Among HIV+ children, HAART versus no HAART showed no significant difference in the odds of dental caries by DMFT in cross-sectional studies (OR 1.29, 95% CI 0.59 to 2.84; ungraded).

2 findings from 1 review

HIV-infected children on antiretroviral therapy (HI) vs HIV-unexposed uninfected children (HUU)

Dental caries · Children and adolescents (<18 years) living with HIV (CLWH)

HIV-infected children on ART had higher odds of dental caries than HUU children in case-control studies (OR 1.61, 95% CI 1.02 to 2.56; ungraded).

2 findings from 1 review

Intervention not reported

Dental caries in permanent teeth · Children (permanent dentition) worldwide

In Africa, the pooled prevalence of permanent-teeth caries in children was 58.9% (95% CI 29.4 to 83.1); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in permanent teeth · Children (permanent dentition) worldwide

In Europe, the pooled prevalence of permanent-teeth caries in children was 44.1% (95% CI 36.1 to 52.5); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in permanent teeth · Children (permanent dentition) worldwide

In Australia, the pooled estimate of permanent-teeth caries prevalence in children was 54.9% (95% CI 50.9 to 58.8) from a single study; certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in permanent teeth · Children (permanent dentition) worldwide

The pooled worldwide prevalence of dental caries in permanent teeth in children was 53.8% (95% CI 50.0 to 57.5), with very high heterogeneity (I2=99.8%); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in permanent teeth · Children (permanent dentition) worldwide

In the Americas, the pooled prevalence of permanent-teeth caries in children was 48.9% (95% CI 37.6 to 60.3); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in permanent teeth · Children (permanent dentition) worldwide

In Asia, the pooled prevalence of permanent-teeth caries in children was 58.8% (95% CI 53.4 to 64.0); certainty not graded.

1 finding from 1 review

ADGRL2 gene (aggregate gene-based signal, MAGMA) vs Genome-wide gene background (FDR threshold)

Dental caries (self-reported history) · Japanese adults (present-study direct-to-consumer genetic testing cohort); self-reported disease cases vs controls

Gene-based analysis found ADGRL2 significantly associated with dental caries (FDR q<0.05); ungraded.

1 finding from 1 review
  • Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomes
    Lifelong (germline genotype) · Population-based genetic association study (Japanese direct-to-consumer genetic testing cohort) · MAGMA gene-based test (present study)
    Gene-based association analysis (MAGMA): ADGRL2 was the only gene associated with dental caries at false-discovery-rate q<0.05 (no effect size reported).
    1 study · 45525 participants
    GRADE not reported

High-frequency sugar consumption (three or more times daily) vs Low sugar intake (fewer than three times daily)

Dental caries prevalence · Nigerian individuals, including children and adults, with primary or permanent dentition

High-frequency sugar consumption was associated with 18% higher but non-significant odds of dental caries in Nigeria (OR 1.18, 95% CI 0.87 to 1.59; I2=36%; ungraded).

1 finding from 1 review

Illicit drug use vs People who do not use drugs

DMFT/DMFS index (dental caries experience) · People who use drugs (PWUD): methamphetamine, heroin, opiate, cannabis and cocaine users

Illicit drug use was associated with substantially higher odds of dental caries experience (DMFT) (pooled OR 4.11, 95% CI 2.07-8.15; 7 studies; high heterogeneity I2=90.5%; ungraded).

1 finding from 1 review