HIV-infected children on antiretroviral therapy (HI) vs HIV-exposed but uninfected children (HEU): Dental caries
- Population
- Children and adolescents (<18 years) living with HIV (CLWH)
- Intervention
- HIV-infected children on antiretroviral therapy (HI)
- Comparison
- HIV-exposed but uninfected children (HEU)
- Outcome
- Dental caries
HIV-infected children on ART had higher odds of dental caries than HEU children in a cohort study (OR 2.88, 95% CI 1.71 to 4.84; ungraded).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
HIV-infected children on antiretroviral therapy (HI) vs HIV-exposed but uninfected children (HEU) Dental caries (presence/absence) · Children and adolescents under 18 years with HIV · Prospective follow-up, Dental examination of children/adolescents with HIV in clinic and community settings; low- and middle-income countries (Brazil, India, Nigeria, Cambodia, Uganda, West Africa), Cohort studies HIV-infected children on ART had higher odds of dental caries than HEU children in a cohort study (OR 2.88, 95% CI 1.71 to 4.84; ungraded). Association between antiretroviral therapy and dental caries in children and adolescents with HIV: a… (2025) All outcomes | OR 2.88 [1.71, 4.84] | Not reported | GRADE not reported |
HIV-infected children on antiretroviral therapy (HI) vs HIV-exposed but uninfected children (HEU) Dental caries (presence/absence) · Children and adolescents under 18 years with HIV · Not specified (cross-sectional), Dental examination of children/adolescents with HIV in clinic and community settings; low- and middle-income countries (Brazil, India, Nigeria, Cambodia, Uganda, West Africa), Cross-sectional studies HIV-infected children on ART had higher odds of dental caries than HIV-exposed uninfected (HEU) children in cross-sectional studies (OR 3.73, 95% CI 1.88 to 7.40; ungraded). Association between antiretroviral therapy and dental caries in children and adolescents with HIV: a… (2025) All outcomes | OR 3.73 [1.88, 7.40] | Not reported | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Association between antiretroviral therapy and dental caries in children and adolescents with HIV: a systematic review and meta-analysis. 2025 All outcomes | Inception to October 2024 (LILACS expanded search updated February 2025) | 17 | Not applicable |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- HIV-infected children on antiretroviral therapy (HI) vs HIV-unexposed uninfected children (HUU) · Children and adolescents (<18 years) living with HIV (CLWH) · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.