Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

217 questions · 219 findings · 80 reviews · Headline outcomes only

No studies found 48 · 21.9%GRADE not reported 12 · 5.5%Very low 57 · 26%Low 57 · 26%Moderate 36 · 16.4%High 9 · 4.1%

Interventions for vs no intervention

Number of deaths due to SUDEP: Nocturnal supervision compared to no supervision · cases of SUDEP and matched controls (number of deaths due to SUDEP) and consecutive people with epilepsy from a tertiary care teaching…
2 findings from 1 review

Interventions for vs no intervention

Number of deaths due to SUDEP: Special precautions compared to no special precautions · cases of SUDEP and matched controls (number of deaths due to SUDEP) and consecutive people with epilepsy from a tertiary care teaching…

It is very uncertain whether interventions for changes number of deaths due to SUDEP: special precautions compared to no… compared with no intervention (very low certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in death by any cause compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes adverse events: death (secondary outcome) compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Mediterranean dietary intervention vs another dietary intervention

Total cardiac endpoints (all‐cause and cardiac deaths, myocardial infarction, hospital admissions for heart failure, unstable angina or stroke, unadjusted) · adults with established cardiovascular disease

It is very uncertain whether mediterranean dietary intervention changes total cardiac endpoints (all‐cause and cardiac deaths, myocardial… compared with another dietary intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: death (secondary outcome) compared with placebo (very low certainty).

1 finding from 1 review