Findings

What do systematic reviews say?

8 questions · 8 findings · 4 reviews · Stroke

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 25%Low 3 · 37.5%Moderate 1 · 12.5%High 2 · 25%

Endovascular treatment vs standard‐of‐care therapy

Death at · people with stroke upon awakening

Endovascular treatment showed no clear difference in death at compared with standard medical care (high certainty).

1 finding from 1 review

Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake‐up stroke 2021 · Cochrane Headline outcomes only
RR 0.68 [0.43, 1.07]
2 studies · 205 participants
High

Endovascular therapy plus conventional medical treatment vs conventional medical treatment alone

Death · people with symptomatic intracranial artery stenosis

Endovascular therapy plus conventional medical treatment may leads to higher death compared with conventional medical treatment alone (low certainty).

1 finding from 1 review

Endovascular therapy versus medical treatment for symptomatic intracranial artery stenosis 2023 · Cochrane Headline outcomes only
RR 5.43 [1.21, 24.4]
4 studies · 989 participants
Low

Endovascular therapy plus conventional medical treatment vs conventional medical treatment alone

Death or stroke · people with symptomatic intracranial artery stenosis

Endovascular therapy plus conventional medical treatment probably leads to higher death or stroke compared with conventional medical treatment alone (moderate certainty).

1 finding from 1 review

Endovascular therapy versus medical treatment for symptomatic intracranial artery stenosis 2023 · Cochrane Headline outcomes only
RR 2.93 [1.81, 4.75]
4 studies · 989 participants
Moderate

Endovascular therapy plus conventional medical treatment vs medical treatment

DeathMedian · people with vertebral artery stenosis

Endovascular treat ment plus medical treatment showed no clear difference in deathMedian compared with medical treatment alone (low certainty).

1 finding from 1 review

Percutaneous transluminal angioplasty and stenting for vertebral artery stenosis 2022 · Cochrane Headline outcomes only
RR 0.78 [0.37, 1.62]
3 studies · 349 participants
Low

Endovascular therapy plus conventional medical treatment vs medical treatment

Death or stroke · people with vertebral artery stenosis

Endovascular treat ment plus medical treatment showed no clear difference in 30‐day post‐randomisation death/stroke compared with medical treatment alone (low certainty).

1 finding from 1 review

Percutaneous transluminal angioplasty and stenting for vertebral artery stenosis 2022 · Cochrane Headline outcomes only
RR 2.33 [0.77, 7.07]
3 studies · 349 participants
Low

Conservative treatment vs endovascular coiling

Death · people with unruptured intracranial aneurysms

1 finding from 1 review

Treatments for unruptured intracranial aneurysms 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 80 participants
Very low

Intravenous thrombolytic treatment vs standard‐of‐care therapy

Death at · people with stroke upon awakening

Intravenous thrombolytic treatment showed no clear difference in death at compared with standard medical care (high certainty).

1 finding from 1 review

Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake‐up stroke 2021 · Cochrane Headline outcomes only
RR 0.68 [0.43, 1.07]
5 studies · 763 participants
High

Microsurgical clipping vs endovascular coiling

Death · people with unruptured intracranial aneurysms

1 finding from 1 review

Treatments for unruptured intracranial aneurysms 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 106 participants
Very low