Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

24 questions · 24 findings · 15 reviews

No studies found 2 · 8.3%GRADE not reported 0 · 0%Very low 10 · 41.7%Low 10 · 41.7%Moderate 2 · 8.3%High 0 · 0%

IVF vs expectant management

Clinical pregnancy rate · women with unexplained subfertility

It is very uncertain whether IVF changes clinical pregnancy rate per woman randomised compared with expectant management (very low certainty).

1 finding from 1 review

IVF vs unstimulated IUI

Clinical pregnancy rate · women with unexplained subfertility

It is very uncertain whether IVF changes clinical pregnancy rate per woman randomised compared with unstimulated IUI (very low certainty).

1 finding from 1 review

Any glucocorticoid vs no glucocorticoids or placebo

Clinical pregnancy rate per couple – subgroup IVF · assisted reproduction technology cycles

It is very uncertain whether glucocorticoids changes clinical pregnancy rate per couple – subgroup IVF compared with no glucocorticoids or placebo (very low certainty).

1 finding from 1 review

G‐CSF vs no treatment or placebo

Clinical pregnancy rate ‐ unselected or unstated IVF number · Subfertile women undergoing assisted reproduction

G‐CSF showed no clear difference in clinical pregnancy rate ‐ unselected or unstated IVF number compared with no treatment or placebo (low certainty).

1 finding from 1 review

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Clinical pregnancy rate · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

It is very uncertain whether day 3 changes clinical pregnancy rate per woman compared with day 2 embryo transfer following IVF or ICSI (very low certainty).

1 finding from 1 review

Transvaginal aspiration of hydrosalpingeal fluid vs laparoscopic salpingectomy

Clinical pregnancy rate · tubal disease in women due to undergo in vitro fertilisation

It is very uncertain whether transvaginal aspiration of hydrosalpingeal fluid changes clinical pregnancy rate compared with laparoscopic salpingectomy (very low certainty).

1 finding from 1 review

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Clinical pregnancy rate · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) showed no clear difference in clinical pregnancy rate compared with multiple embryo transfer (low certainty).

1 finding from 1 review

Long‐term GnRH agonist therapy vs no additional therapy

Clinical pregnancy rate · patients with endometriosis prior to standard IVF/ICSI

It is very uncertain whether long‐term GnRH agonist therapy changes clinical pregnancy rate compared with no additional therapy (very low certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · Women undergoing controlled ovarian stimulation in IVF and ICSI cycles (poor responders)

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonist or midcycle antagonist) (low certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · for controlled ovarian stimulation

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonists or midcycle antagonist) (moderate certainty).

1 finding from 1 review