Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

21 questions · 22 findings · 13 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 8 · 36.4%Low 10 · 45.5%Moderate 4 · 18.2%High 0 · 0%

IVF vs expectant management

Clinical pregnancy rate · women with unexplained subfertility

It is very uncertain whether IVF changes clinical pregnancy rate per woman randomised compared with expectant management (very low certainty).

1 finding from 1 review

IVF vs unstimulated IUI

Clinical pregnancy rate · women with unexplained subfertility

It is very uncertain whether IVF changes clinical pregnancy rate per woman randomised compared with unstimulated IUI (very low certainty).

1 finding from 1 review

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Clinical pregnancy rate · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

It is very uncertain whether day 3 changes clinical pregnancy rate per woman compared with day 2 embryo transfer following IVF or ICSI (very low certainty).

1 finding from 1 review

Monitoring ovarian stimulation by transvaginal ultrasound (TVUS) only vs monitoring with TVUS plus serum estradiol

Clinical pregnancy · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

Monitoring ovarian stimulation by transvaginal ultrasound (TVUS) only showed no clear difference in clinical pregnancy per woman compared with monitoring with TVUS plus serum estradiol (low certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · Women undergoing controlled ovarian stimulation in IVF and ICSI cycles (poor responders)

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonist or midcycle antagonist) (low certainty).

1 finding from 1 review

Ultrasound‐guided embryo transfer vs clinical touch

Clinical pregnancies Number of clinical pregnancies per woman randomised · Women undergoing embryo transfer as part of IVF or ICSI cycle

Ultrasound‐guided embryo transfer probably leads to higher clinical pregnancy (per woman randomised) compared with clinical touch (moderate certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · for controlled ovarian stimulation

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonists or midcycle antagonist) (moderate certainty).

1 finding from 1 review

Metformin vs placebo or no treatment

Clinical pregnancy rate · women with polycystic ovary syndrome

It is very uncertain whether metformin changes clinical pregnancy rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (very low certainty).

1 finding from 1 review · compare the 2 reviews

Endometrial injury vs control

Clinical pregnancy per woman randomised: sensitivity analysis (no high‐risk) · women undergoing assisted reproduction

Endometrial injury showed no clear difference in clinical pregnancy per woman randomised: sensitivity analysis (no… compared with control (low certainty).

1 finding from 1 review