Findings

What do systematic reviews say?

10 questions · 10 findings · 5 reviews · Haematology

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No studies found 5 · 50%GRADE not reported 1 · 10%Very low 3 · 30%Low 1 · 10%Moderate 0 · 0%High 0 · 0%

Prophylactic platelet transfusion prior to surgery vs no prophylactic platelet transfusion prior to surgery

All‐cause mortality within 30 days of surgery · people with a low platelet count

It is very uncertain whether prophylactic platelet transfusion prior to surgery changes all‐cause mortality within 30 days of surgery compared with no prophylactic platelet transfusion prior to surgery (very low certainty).

1 finding from 1 review

Prophylactic platelet transfusions prior to surgery for people with a low platelet count 2018 · Cochrane Headline outcomes only
RR 0.78 [0.41, 1.45]
1 study · 72 participants
Very low

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

All‐cause mortality up to 30 days № of participants: 72 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether prophylactic plasma transfusion before surgery/invasive procedures changes all‐cause mortality up to 30 days № of participants: 72 (1 RCT) compared with no prophylactic plasma transfusion before surgery/invasive… (very low certainty).

1 finding from 1 review

Prophylactic plasma transfusion for patients without inherited bleeding disorders or anticoagulant use undergoing… 2019 · Cochrane Headline outcomes only
RR 0.38 [0.13, 1.1]
Studies not reported
Very low

Prophylactic platelet transfusion prior to surgery vs alternative treatment

All‐cause mortality within 30 days of surgery – not reported · people with a low platelet count

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic platelet transfusions prior to surgery for people with a low platelet count 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Prophylactic plasma transfusion before surgery/invasive procedures vs alternative haemostatic agents

All‐cause mortality up to 30 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic plasma transfusion for patients without inherited bleeding disorders or anticoagulant use undergoing… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

MSCs vs placebo or control

Death during study period · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

MSCs showed no clear difference in all‐cause mortality (prophylactic trials) (over duration of trial) compared with control/placebo (low certainty).

1 finding from 1 review

Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft‐versus‐host disease in haematopoietic… 2019 · Cochrane Headline outcomes only
HR 0.85 [0.5, 1.42]
5 studies · 301 participants
Low

Thrombopoietin mimetics vs placebo or usual care

All‐cause mortality · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

1 finding from 1 review

Alternatives, and adjuncts, to prophylactic platelet transfusion for people with haematological malignancies… 2016 · Cochrane Headline outcomes only
no estimate extracted
4 participants
GRADE not reported

Thrombopoietin mimetics vs placebo

All‐cause mortality · People with chronic bone marrow failure

It is very uncertain whether thrombopoietin mimetic changes all‐cause mortality compared with placebo (very low certainty).

1 finding from 1 review

Alternative agents to prophylactic platelet transfusion for preventing bleeding in people with thrombocytopenia due to… 2016 · Cochrane Headline outcomes only
RR 0.74 [0.52, 1.05]
5 studies · 456 participants
Very low

Intervention not reported

All‐cause mortality ‐ not reported · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

The review found no eligible studies for this question.

1 finding from 1 review

Alternatives, and adjuncts, to prophylactic platelet transfusion for people with haematological malignancies… 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Thromboelastography threshold vs standard of care (laboratory parameters)

All‐cause mortality up to 30 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic plasma transfusion for patients without inherited bleeding disorders or anticoagulant use undergoing… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

All‐cause mortality within 30 days of surgery – not reported · people with a low platelet count

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic platelet transfusions prior to surgery for people with a low platelet count 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found