What do systematic reviews say?

Intervention not reported

The intervention showed no clear difference in all‐cause mortality (low certainty).

• Social network interventions to support cardiac rehabilitation and secondary prevention in the management of people… 2023 · Cochrane Headline outcomes only
  RR 0.75 [0.49, 1.13]
  6 studies · 3093 participants
  Low

Sildenafil vs Placebo or no active treatment

Sildenafil citrate showed no clear difference in all‐cause mortality compared with placebo or no therapy (moderate certainty).

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  RR 1.01 [0.8, 1.27]
  5 studies · 516 participants
  Moderate

Sildenafil vs IV nitroglycerin

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Tadalafil vs Placebo or no active treatment

Tadalafil showed no clear difference in all‐cause mortality compared with placebo or no therapy (low certainty).

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  RR 0.2 [0.02, 1.6]
  1 study · 87 participants
  Low

Nitroglycerin vs Placebo or no active treatment

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Heparin vs pentasaccharide

• Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 198 participants
  Very low

Heparin started before vs after the surgical procedure

• Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  Very low

IPC plus pharmacological prophylaxis vs mechanical prophylaxis alone

• Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 150 participants
  Low

Higher‐dose heparin vs standard‐dose heparin

• Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 597 participants
  Low

Transfusions continued vs transfusions halted

It is very uncertain whether transfusions continued changes all‐cause mortality compared with transfusions halted (very low certainty).

• Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
  Peto OR 8 [0.16, 404.12]
  1 study · 79 participants
  Very low

Long‐term red cell transfusion vs usual care

• Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 196 participants
  Low

Hydroxyurea vs RBC transfusion

• Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1 participants
  Very low

Hydroxyurea vs RBC transfusion

It is very uncertain whether hydroxyurea changes all‐cause mortality compared with RBC transfusion (very low certainty).

• Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
  OR 1.02 [0.06, 16.41]
  1 study · 133 participants
  Very low

Long‐term red cell transfusion vs usual care

• Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 130 participants
  Very low

Multidisciplinary disease management programmes vs usual care

Multidisciplinary disease management programmes probably leads to lower all‐cause mortality compared with usual care (moderate certainty).

• Disease management interventions for heart failure 2019 · Cochrane Headline outcomes only
  RR 0.67 [0.54, 0.83]
  8 studies · 1764 participants
  Moderate

Case management vs usual care

Case management may leads to lower all‐cause mortality compared with usual care (low certainty).

• Disease management interventions for heart failure 2019 · Cochrane Headline outcomes only
  RR 0.78 [0.68, 0.9]
  26 studies · 6903 participants
  Low

Intervention not reported

It is very uncertain whether the intervention changes all‐cause mortality (very low certainty).

• Pharmacological interventions for prevention and treatment of upper gastrointestinal bleeding in newborn infants 2019 · Cochrane Headline outcomes only
  RR 2.42 [0.7, 8.38]
  1 study · 53 participants
  Very low

Intervention not reported

The intervention showed no clear difference in all‐cause mortality (low certainty).

• Pharmacological interventions for prevention and treatment of upper gastrointestinal bleeding in newborn infants 2019 · Cochrane Headline outcomes only
  RR 0.63 [0.26, 1.51]
  2 studies · 131 participants
  Low

Intervention not reported

The review found no eligible studies for this question.

• Interventions for treating acute high altitude illness 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Interventions for treating acute high altitude illness 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found