What do systematic reviews say?

Long‐term red cell transfusion vs usual care

• Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 130 participants
  Very low

Multidisciplinary disease management programmes vs usual care

Multidisciplinary disease management programmes probably leads to lower all‐cause mortality compared with usual care (moderate certainty).

• Disease management interventions for heart failure 2019 · Cochrane Headline outcomes only
  RR 0.67 [0.54, 0.83]
  8 studies · 1764 participants
  Moderate

Case management vs usual care

Case management may leads to lower all‐cause mortality compared with usual care (low certainty).

• Disease management interventions for heart failure 2019 · Cochrane Headline outcomes only
  RR 0.78 [0.68, 0.9]
  26 studies · 6903 participants
  Low

Clinic‐based intervention vs usual care

Clinic‐based intervention showed no clear difference in all‐cause mortality compared with usual care (low certainty).

• Disease management interventions for heart failure 2019 · Cochrane Headline outcomes only
  RR 0.87 [0.68, 1.1]
  7 studies · 1686 participants
  Low

Intervention not reported

It is very uncertain whether the intervention changes all‐cause mortality (very low certainty).

• Pharmacological interventions for prevention and treatment of upper gastrointestinal bleeding in newborn infants 2019 · Cochrane Headline outcomes only
  RR 2.42 [0.7, 8.38]
  1 study · 53 participants
  Very low

Intervention not reported

The intervention showed no clear difference in all‐cause mortality (low certainty).

• Pharmacological interventions for prevention and treatment of upper gastrointestinal bleeding in newborn infants 2019 · Cochrane Headline outcomes only
  RR 0.63 [0.26, 1.51]
  2 studies · 131 participants
  Low

Intervention not reported

The review found no eligible studies for this question.

• Interventions for treating acute high altitude illness 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Interventions for treating acute high altitude illness 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Diet, physical activity and behavioural interventions for the treatment of overweight or obese children from the age… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Diet, physical activity and behavioural interventions for the treatment of overweight or obese adolescents aged 12 to… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Carvedilol vs placebo

It is very uncertain whether carvedilol changes all‐cause mortality compared with placebo (very low certainty).

• Pharmacological interventions for treating heart failure in patients with Chagas cardiomyopathy 2016 · Cochrane Headline outcomes only
  RR 0.69 [0.12, 3.88]
  2 studies · 69 participants
  Very low

Rosuvastatin vs placebo

• Pharmacological interventions for treating heart failure in patients with Chagas cardiomyopathy 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 39 participants
  GRADE not reported

Intervention not reported

The review found no eligible studies for this question.

• Self management interventions for type 2 diabetes in adult people with severe mental illness 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Diet, physical activity, and behavioural interventions for the treatment of overweight or obesity in preschool… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Diet, physical activity, and behavioural interventions for the treatment of overweight or obesity in preschool… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Drug interventions for the treatment of obesity in children and adolescents 2016 · Cochrane Headline outcomes only
  no estimate extracted
  20 studies · 2176 participants
  Moderate

Amiodarone vs other antiarrhythmics

Amiodarone showed no clear difference in all‐cause mortality compared with other antiarrhythmics (low certainty).

• Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
  RR 1.03 [0.75, 1.42]
  5 studies · 898 participants
  Low

Amiodarone vs beta‐blocker

It is very uncertain whether amiodarone changes all‐cause mortality compared with beta blockers (very low certainty).

• Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
  RR 0.96 [0.7, 1.32]
  1 study · 189 participants
  Very low

Amiodarone vs sotalol

It is very uncertain whether amiodarone changes all‐cause mortality compared with sotalol (very low certainty).

• Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
  RR 1.08 [0.41, 2.83]
  2 studies · 104 participants
  Very low

Amiodarone vs placebo or no treatment

Amiodarone showed no clear difference in all‐cause mortality compared with placebo or no treatment (low certainty).

• Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
  RR 0.88 [0.78, 1]
  17 studies · 8383 participants
  Low