Findings

What do systematic reviews say?

13 questions · 13 findings · 6 reviews · Pain, Palliative and Supportive Care

Sort:Best matchNewest Highest certainty Download CSV

No studies found 2 · 15.4%GRADE not reported 5 · 38.5%Very low 1 · 7.7%Low 2 · 15.4%Moderate 2 · 15.4%High 1 · 7.7%

Decompressive surgery plus radiotherapy vs radiotherapy

Adverse events · adults with metastatic extradural spinal cord compression (fit for surgery, paraplegic less than 48 hours, and without multiple discrete…

1 finding from 1 review

Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 101 participants
GRADE not reported

Summary of findings: liposomal bupivacaine vs bupivacaine

Incidence of adverse events within 30 days of surgery · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 583 participants
Moderate

Summary of findings: liposomal bupivacaine vs placebo

Incidence of adverse events within 30 days of surgery · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 382 participants
Low

Intervention not reported

Incidence of adverse events within 30 days of surgery · adults aged ≥ 18 years undergoing elective surgery at any surgical site

The review found no eligible studies for this question.

1 finding from 1 review

Liposomal bupivacaine peripheral nerve block for the management of postoperative pain 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Dexamethasone vs placebo

Adverse events · participants with advanced cancer who have nausea and vomiting not related to chemotherapy, radiotherapy, or surgery

The review found no eligible studies for this question.

1 finding from 1 review

Corticosteroids for adult patients with advanced cancer who have nausea and vomiting (not related to chemotherapy,… 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Perioperative infraorbital nerve block vs Intravenous analgesia

Adverse events · Children up to 13 years of age, undergoing cleft lip repair surgery

1 finding from 1 review

Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
2 out of 3 studies reported this outcome. Both studies reported no difference between groups (Rajamani 2007 and Simion 2008: no adverse events attributable to either technique; Delgado 2005 did not report).
2 studies
GRADE not reported

Perioperative infraorbital nerve block vs Placebo (sham/placebo device)

Adverse events · Children up to 13 years of age, undergoing cleft lip repair surgery

1 finding from 1 review

Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
2 out of 3 studies reported this outcome. One study reported no differences between groups, and the other study reported more vomiting in the placebo group (Takmaz 2009: vomiting 40% placebo versus 10% intervention; P…
2 studies
GRADE not reported

Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration)

Adverse events · Children up to 13 years of age, undergoing cleft lip repair surgery

1 finding from 1 review

Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
Of the 2 included studies, one study reported no difference between groups (Gaonkar 2004: no adverse events attributable to either technique), and the other study did not report this outcome.
1 study
GRADE not reported

Laminectomy plus radiotherapy vs radiotherapy

Adverse events · adults with metastatic extradural spinal cord compression (single lesion, no prior radiotherapy, fit for surgery)

1 finding from 1 review

Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 29 participants
GRADE not reported

Perioperative intravenous ketamine vs placebo

CNS adverse events · adults undergoing surgery

1 finding from 1 review

Perioperative intravenous ketamine for acute postoperative pain in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
105 studies · 6538 participants
High

Summary of findings: liposomal bupivacaine vs placebo

Serious adverse events · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 382 participants
Low

Summary of findings: liposomal bupivacaine vs bupivacaine

Serious adverse events · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 583 participants
Moderate

Intervention not reported

Serious adverse events · adults aged ≥ 18 years undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine peripheral nerve block for the management of postoperative pain 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low