Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

18 questions · 21 findings · 11 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 8 · 38.1%GRADE not reported 0 · 0%Very low 5 · 23.8%Low 4 · 19%Moderate 4 · 19%High 0 · 0%

Neoadjuvant chemotherapy prior to interval surgery (NACT) vs surgery followed by chemotherapy (PDS)

Surgically‐related severe adverse effects (grade 3+) ‐ postoperative G3+ events (within 30 days of surgery) · women with advanced ovarian epithelial cancer

Neoadjuvant chemotherapy prior to interval surgery (NACT) probably leads to lower surgically‐related severe adverse effects (grade 3+) ‐ postoperative… compared with surgery followed by chemotherapy (PDS) (moderate certainty).

1 finding from 1 review

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery

Adverse events · people with single or solitary brain metastasis

It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events compared with stereotactic radiosurgery (very low certainty).

1 finding from 1 review

iMRI image‐guided surgery vs surgery

Adverse events · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

5‐ALA image‐guided surgery vs surgery

Adverse events · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery

Adverse events (severe) · people with single or solitary brain metastasis

It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (severe) compared with stereotactic radiosurgery (very low certainty).

1 finding from 1 review

Neuronavigation image‐guided surgery vs surgery

Adverse events · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery

Adverse events (moderate) · people with single or solitary brain metastasis

It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (moderate) compared with stereotactic radiosurgery (very low certainty).

1 finding from 1 review

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery plus WBRT

Adverse events (moderate) · people with single or solitary brain metastasis

It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (moderate) compared with stereotactic radiosurgery plus WBRT (very low certainty).

1 finding from 1 review

Suprapubic catheterisation vs intermittent self‐catheterisation

Adverse events (acute complication after surgery)

It is very uncertain whether suprapubic catheterisation changes adverse events (acute complication after surgery) compared with intermittent self‐catheterisation (very low certainty).

1 finding from 1 review

Laparoscopy vs laparotomy

Serious adverse events (range of outcomes) · adult women diagnosed with early stage (I to IIa) endometrial cancer undergoing surgery as primary treatment.

Laparoscopy showed no clear difference in serious adverse events (range of outcomes) compared with laparotomy (low certainty).

1 finding from 1 review

Intervention not reported

Genitourinary adverse events (grade 3 or 4) · patients with early‐stage cervical cancer (FIGO stages IB1, IB2 or IIA)

The intervention showed no clear difference in genitourinary adverse events (grade 3 or 4) (moderate certainty).

1 finding from 1 review

Intervention not reported

Haematological adverse events (grade 3 or 4) · patients with early‐stage cervical cancer (FIGO stages IB1, IB2 or IIA)

The intervention showed no clear difference in haematological adverse events (grade 3 or 4) (moderate certainty).

1 finding from 1 review

Intervention not reported

Gastrointestinal adverse events (grade 3 or 4) · patients with early‐stage cervical cancer (FIGO stages IB1, IB2 or IIA)

The intervention showed no clear difference in gastrointestinal adverse events (grade 3 or 4) (moderate certainty).

1 finding from 1 review