Findings

What do systematic reviews say?

27 questions · 27 findings · 8 reviews · Oral and maxillofacial surgery

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No studies found 4 · 14.8%GRADE not reported 23 · 85.2%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Any surgical or non-surgical technique or material used for the treatment of post-extraction bleeding vs Placebo, no treatment, or another active antifungal intervention

Adverse events · People of any age and either gender with post-extraction bleeding, regardless of type of teeth (anterior or posterior, mandibular or…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating post‐extraction bleeding 2018 · Cochrane All outcomes
No data are available as no RCTs have been conducted on interventions to treat post-extraction bleeding
0 studies
No studies found

Low‐level laser therapy vs Placebo (sham) laser therapy

Adverse events · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes
SoF row 'Adverse events': This outcome was not reported in the included studies.
0 studies
No studies found

Chlorhexidine gel (0.2%, intrasocket) vs placebo or no treatment

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
No adverse events were reported. Six trials (673 participants) reported no adverse events from the use of chlorhexidine gel; one study (Rubio-Palau 2015) reported gastrointestinal discomfort (30, 18%), dizziness (10,…
7 studies
GRADE not reported

Chlorhexidine gel (0.2%, intrasocket) vs Chlorhexidine mouthrinse

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
No adverse events were reported in these two trials (Abu-Mostafa 2015; Hita-Iglesias 2008).
2 studies
GRADE not reported

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) vs placebo or no treatment

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
3 trials reported no adverse events. 1 study reported adverse events (alterations in taste, bad taste, staining) in 24/62 in chlorhexidine group versus 0/40 in placebo group, Peto OR = 8.42 (95% CI 3.31 to 21.39). A…
6 studies
GRADE not reported

Autologous platelet‐rich plasma vs placebo or no treatment

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
No adverse events were reported in these two trials.
2 studies
GRADE not reported

Any experimental intervention (surgical or non-surgical) vs None (placebo or no treatment)

Adverse events · People of any age and either sex, in any setting, with BRONJ; bisphosphonate exposure past or current; includes people with cancer and…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Calcitonin (salmon calcitonin nasal spray 200 IU/day) vs placebo

Adverse events · Patients with histologically confirmed CGCG in one or both jaws and normal serum calcium and parathyroid hormone (PTH) levels

1 finding from 1 review

Interventions for central giant cell granuloma (CGCG) of the jaws 2009 · Cochrane All outcomes
Adverse events were not described separately for each group. Trialists reported that adverse events were in most patients minimal and consisted of nausea, flushes and some dizziness. One patient had diarrhoea which…
1 study · 14 participants
GRADE not reported

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Adverse events · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for central giant cell granuloma (CGCG) of the jaws 2009 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Oral propranolol vs placebo

Adverse events ‐ treatment emergent · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
1 week per period (cross-over)
Tchivileva et al 2010: at least one treatment-emergent adverse event was reported by five participants (12.5%) during the propranolol period (nausea, diarrhoea, insomnia, dizziness, fatigue) and four participants (10%)…
1 study · 40 participants
GRADE not reported

Two lag screws vs One lag screw (with arch bars and IMF)

Post-operative adverse events and complications · Adults (16 to 68 years) with mandibular fractures excluding condylar involvement

1 finding from 1 review

Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
Three participants in the two-lag-screws group experienced complications: malocclusion (one) and mental-nerve paraesthesia (two, resolved after 3 months). There were no post-operative complications in the one-lag-screw…
1 study
GRADE not reported

3-dimensional (3D) miniplates vs Standard (Champy) plates

Post-operative adverse events and complications · Adults (16 to 68 years) with mandibular fractures excluding condylar involvement

1 finding from 1 review

Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
Jain 2010 (3D group): segmental mobility (two), proximity to mental nerve or roots (two), radiologically unsatisfactory reduction (one) and unsatisfactory fixation (four) vs one (standard); only fixation differed…
2 studies
GRADE not reported

Immediate mobilization vs 2 weeks delayed mobilization (IMF)

Post-operative adverse events and complications · Adults with mandibular fractures excluding condyles (fixed with 2 mm titanium miniplates)

1 finding from 1 review

Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
One wound separation and one infection in the immediate-mobilization group. Inferior alveolar nerve status (scale 1 to 3) showed no significant difference at 6 weeks (P=0.76), 3 months (P=0.87) or 6 months (P=0.99).…
1 study
GRADE not reported