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Evidence found and GRADE certainty

13 questions · 13 findings · 7 reviews · Headline outcomes only

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No studies found 2 · 15.4%GRADE not reported 0 · 0%Very low 5 · 38.5%Low 3 · 23.1%Moderate 3 · 23.1%High 0 · 0%

Doxycycline vs quinolones

Adverse events (Analysis 1.7) Participant's report · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

It is very uncertain whether doxycycline changes adverse events Men and women Assessed by participants' self‐report compared with quinolones (very low certainty).

1 finding from 1 review

Doxycycline vs prednisolone

Number of participants with grade 3‐4 (severe or life‐threatening) treatment‐related adverse events at 1 year (raw data) · bullous pemphigoid

Doxycycline probably leads to lower number of participants with grade 3‐4 (severe or life‐threatening)… compared with prednisolone (moderate certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Adverse events considered non‐serious (penicillin versus doxycycline) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes adverse events considered non‐serious (penicillin versus doxycycline) compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Serious adverse events (nosocomial infection) (penicillin versus doxycycline) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes serious adverse events (nosocomial infection) (penicillin versus… compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Serious adverse events (nosocomial infection) (doxycycline versus cefotaxime) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes serious adverse events (nosocomial infection) (doxycycline versus… compared with other antibiotics (very low certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Adverse events Men · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

Azithromycin showed no clear difference in adverse events Men compared with doxycycline (low certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Adverse events Men and women · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

Azithromycin probably leads to lower adverse events Men and women compared with doxycycline (moderate certainty).

1 finding from 1 review

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

Regimens containing macrolides (azithromycin) showed no clear difference in adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing tetracycline (doxycycline) (low certainty).

1 finding from 1 review

Intervention not reported

Number of participants withdrawn due to adverse events (median · participants with osteoarthritis of the knee or hip

The intervention may leads to higher number of participants withdrawn due to adverse events (median (low certainty).

1 finding from 1 review