Question · asked by 1 review
Doxycycline vs prednisolone: Number of participants with grade 3‐4 (severe or life‐threatening) treatment‐related adverse events at 1 year (raw data)
- Population
- bullous pemphigoid
- Intervention
- Doxycycline
- Comparison
- prednisolone
- Outcome
- Number of participants with grade 3‐4 (severe or life‐threatening) treatment‐related adverse events at 1 year (raw data)
Doxycycline probably leads to lower number of participants with grade 3‐4 (severe or life‐threatening)… compared with prednisolone (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Doxycycline vs prednisolone Number of participants with grade 3‐4 (severe or life‐threatening) treatment‐related adverse events at 1 year (raw data) · bullous pemphigoid Doxycycline probably leads to lower number of participants with grade 3‐4 (severe or life‐threatening)… compared with prednisolone (moderate certainty). Interventions for bullous pemphigoid (2023) · Cochrane Headline outcomes only | RR 0.59 [0.35, 0.99] | 1 study · 234 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.