Cochrane · systematic review · CD011146
Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis
Abegunde, AT, Ahuja, RM, Okafor, NJ · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 83.3%Low 0 · 0%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: people residing in communities endemic for onchocerciasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement in visual impairment at 6 months | RR 1.06 [0.8, 1.39] | 1 study · 240 participants | Very low Downgraded: risk of bias, imprecision |
Parasitological outcomes | no estimate extracted | NR | Very low Downgraded: risk of bias |
Clinical outcomes: improvement in optic atrophy, chorioretinitis, or sclerosing keratitis at 6 months | no estimate extracted | NR | Very low Downgraded: risk of bias |
Clinical outcomes: improvement in iridocyclitis at 6 months | RR 1.24 [0.69, 2.22] | 1 study · 240 participants | Very low Downgraded: risk of bias, imprecision |
Clinical outcomes: improvement in punctate keratitis at 6 months | RR 1.43 [1.02, 2] | 1 study · 240 participants | Very low Downgraded: risk of bias |
Adverse events | no estimate extracted | 2010 participants | Moderate Downgraded: risk of bias, imprecision |