Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

260 questions · 267 findings · 107 reviews

No studies found 81 · 30.3%GRADE not reported 43 · 16.1%Very low 66 · 24.7%Low 40 · 15%Moderate 35 · 13.1%High 2 · 0.7%

Tocilizumab every 4 weeks vs placebo

Adverse events at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab every 4 weeks showed no clear difference in adverse events at ≥ 12 months compared with placebo (moderate certainty).

1 finding from 1 review

Tocilizumab weekly vs placebo + 52‐week taper

Adverse events at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly showed no clear difference in adverse events at ≥ 12 months compared with placebo + 52‐week taper (moderate certainty).

1 finding from 1 review

Tocilizumab weekly vs placebo + 26‐week taper

Adverse events at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly showed no clear difference in adverse events at ≥ 12 months compared with placebo + 26‐week taper (moderate certainty).

1 finding from 1 review

Mechanically assisted walking training with body weight support vs the same dose of overground walking training

Adverse events (not measured) · children with cerebral palsy classified within GMFCS Levels I to IV and between 4 and 18 years of age

The review found no eligible studies for this question.

1 finding from 1 review

Mechanically assisted walking training without body weight support vs the same dose of overground walking training

Adverse events (not measured) · children with cerebral palsy classified within GMFCS Levels I to III and between 3 and 12 years of age

The review found no eligible studies for this question.

1 finding from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Rate of serious adverse events · adults (≥ 18 years of age) with a diagnosis of chronic heart failure with reduced ejection fraction (HFrEF)
2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Rate of serious adverse events · patients with chronic heart failure with preserved ejection fraction
2 findings from 1 review

Antihypertensive drug therapy vs placebo or no treatment

Withdrawals due to adverse events · adults (18 years of age or older) with hypertension‐induced left ventricular hypertrophy

It is very uncertain whether antihypertensive therapy changes withdrawal due to adverse events compared with placebo or no treatment (very low certainty).

1 finding from 1 review