Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

151 questions · 152 findings · 61 reviews

No studies found 20 · 13.2%GRADE not reported 4 · 2.6%Very low 53 · 34.9%Low 39 · 25.7%Moderate 24 · 15.8%High 12 · 7.9%

Intervention not reported

Non‐fatal, serious adverse pneumonia events (requiring hospital admission) · patients with chronic obstructive pulmonary disease

The intervention leads to higher non‐fatal, serious adverse pneumonia events (requiring hospital… (high certainty).

1 finding from 1 review

Intervention not reported

Non‐fatal, serious adverse pneumonia events (requiring hospital admission) · patients with chronic obstructive pulmonary disease

The intervention showed no clear difference in non‐fatal, serious adverse pneumonia events (requiring hospital… (moderate certainty).

1 finding from 1 review

Intervention not reported

Non‐serious adverse eventsClinical manifestation and laboratory examination · people with acute herpes zoster (within 7 days of onset of rash)

The intervention showed no clear difference in non‐serious adverse eventsClinical manifestation and laboratory… (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events-serious events Budesonide/formoterol (BDF) versus budesonide (BD) · patients with COPD

It is very uncertain whether the intervention changes adverse events-serious events Budesonide/formoterol (BDF) versus… (very low certainty).

1 finding from 1 review

Weekend therapy vs no topical corticosteroids

Local adverse events: skin thinning; end of treatment (16‐20 weeks + 2‐4 weeks acute phase) · children and adults with mild to severe eczema

Weekend therapy may leads to lower local adverse events: skin thinning; end of treatment (16‐20 weeks +… compared with no topical corticosteroid (low certainty).

1 finding from 1 review

Weekend therapy vs no topical corticosteroids

Systemic adverse events: abnormal cortisol; end of treatment (16 weeks + 4 weeks acute phase) · children and adults with mild to severe eczema

It is very uncertain whether weekend therapy changes systemic adverse events: abnormal cortisol; end of treatment (16… compared with no topical corticosteroid (very low certainty).

1 finding from 1 review

Corticosteroids vs no corticosteroid use

Number and nature of adverse events secondary to corticosteroid use (hospital‐acquired infection) · individuals with influenza

It is very uncertain whether corticosteroid therapy changes number and nature of adverse events secondary to corticosteroid use… compared with no corticosteroid therapy (very low certainty).

1 finding from 1 review