Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

424 questions · 424 findings · 136 reviews

No studies found 93 · 21.9%GRADE not reported 14 · 3.3%Very low 130 · 30.7%Low 114 · 26.9%Moderate 58 · 13.7%High 15 · 3.5%

Oral retinoids: alitretinoin 30 mg vs placebo

Adverse effects: headache · people with moderate to severe chronic hand eczema

Oral retinoids: alitretinoin 30 mg leads to higher primary: adverse events ‐ headache Folluw‐up: 48 weeks to 72 weeks compared with placebo (high certainty).

1 finding from 1 review

Tramadol in combination with acetaminophen vs placebo

Withdrawals due to adverse events · patients with osteoarthritis

Tramadol in combination with acetaminophen may leads to higher number of participants who withdrew due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Cannabidiol vs AMISULPRIDE

Adverse effects: measured adverse events ‐ medium term ‐ not measured · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Regimens containing quinolone vs regimens containing cephalosporin

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

It is very uncertain whether regimens containing quinolone changes adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing cephalosporins (very low certainty).

1 finding from 1 review

Quinine vs placebo

Minor adverse events · patients with muscle cramps
1 finding from 1 review

Vitamin A vs placebo

Adverse events: minor gastrointestinal symptoms · healthy people and healthy male physicians

Vitamin A leads to higher adverse events: minor gastrointestinal symptoms compared with placebo (high certainty).

1 finding from 1 review

Clindamycin plus aminoglycoside vs regimens containing cephalosporin

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

It is very uncertain whether regimens containing clindamycin plus aminoglycoside changes adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing cephalosporin (very low certainty).

1 finding from 1 review