Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

117 questions · 117 findings · 44 reviews

No studies found 21 · 17.9%GRADE not reported 13 · 11.1%Very low 29 · 24.8%Low 33 · 28.2%Moderate 18 · 15.4%High 3 · 2.6%

Summary of findings: tobramycin for inhalation powder vs tobramycin

Adverse events: number of any adverse event reported · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Summary of findings: tobramycin for inhalation powder showed no clear difference in adverse events: number of any adverse event reported compared with tobramycin (moderate certainty).

1 finding from 1 review

Antibiotic 1 vs antibiotic 2

Adverse events: cotrimoxazole (1) versus cefprozil (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 showed no clear difference in adverse events: cotrimoxazole (1) versus cefprozil (2) compared with antibiotic 2 (low certainty).

1 finding from 1 review

Intramuscular ceftriaxone vs oral amoxicillin plus oral probenecid

Adverse events including treatment‐related adverse events · pregnant women with gonorrhoea infection

It is very uncertain whether intramuscular ceftriaxone changes adverse events including treatment‐related adverse events compared with oral amoxicillin plus oral probenecid (very low certainty).

1 finding from 1 review

Summary of findings: colistimethate dry powder for inhalation (Colobreathe®) vs tobramycin

Adverse events: number of treatment related adverse events · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Summary of findings: colistimethate dry powder for inhalation… may leads to higher adverse events: number of treatment related adverse events compared with tobramycin (low certainty).

1 finding from 1 review

Summary of findings: aztreonam lysine for inhalation vs tobramycin

Adverse events: number of treatment‐related adverse events · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Summary of findings: aztreonam lysine for inhalation probably leads to higher adverse events: number of treatment‐related adverse events compared with tobramycin (moderate certainty).

1 finding from 1 review

Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin

Adverse events: any adverse event in the comparative phase · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Summary of findings: continuous cycles alternating aztreonam lysine… showed no clear difference in adverse events: any adverse event in the comparative phase compared with continuous cycles alternating placebo with tobramycin (low certainty).

1 finding from 1 review

Antibiotic 1 vs antibiotic 2

Adverse events: nitrofurantoin (1) versus trimethoprim (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 may leads to higher adverse events: nitrofurantoin (1) versus trimethoprim (2) compared with antibiotic 2 (low certainty).

1 finding from 1 review

Summary of findings: amikacin liposome inhalation suspension (ALIS) vs tobramycin

Number experiencing adverse effects · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Summary of findings: amikacin liposome inhalation suspension (ALIS) showed no clear difference in adverse events: number of participants experiencing any TEAE compared with tobramycin (moderate certainty).

1 finding from 1 review

Intervention not reported

Incidence of adverse events ‐ co‐trimoxazole prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in incidence of adverse events ‐ co‐trimoxazole prophylaxis only (moderate certainty).

1 finding from 1 review

Doxycycline vs quinolones

Adverse events (Analysis 1.7) Participant's report · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

It is very uncertain whether doxycycline changes adverse events Men and women Assessed by participants' self‐report compared with quinolones (very low certainty).

1 finding from 1 review