Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,041 questions · 1,056 findings · 283 reviews

No studies found 346 · 32.8%GRADE not reported 111 · 10.5%Very low 326 · 30.9%Low 195 · 18.5%Moderate 66 · 6.3%High 12 · 1.1%

Group C cognitive behavioural therapy: cognitive behavioural therapy + risperidone vs placebo or supportive treatment

Adverse effects: specific ‐ doctors' assessment of adverse effects UKU (events) Medium‐term · people in the prodromal stage of psychosis

It is very uncertain whether group C cognitive behavioural therapy: cognitive behavioural therapy… changes adverse effects: doctors' assessment of adverse effects UKU (events)… compared with supportive therapy + placebo (very low certainty).

1 finding from 1 review

Alarm vs other types of alarm

Proportion of children with adverse events ‐ code‐word alarm versus control alarm · children with nocturnal enuresis

Alarm showed no clear difference in proportion of children with adverse events ‐ code‐word alarm versus… compared with other types of alarm (moderate certainty).

1 finding from 1 review

Acyclovir vs placebo, vitamins, or no treatment

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

Acyclovir showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with placebo, vitamins, or no treatment (moderate certainty).

1 finding from 1 review

Clarithromycin vs placebo

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Oral propranolol vs topical timolol

Adverse events experienced at short or long term ‐ general adverse events 24 weeks' · infantile haemangiomas (strawberry birthmarks) of the skin

It is very uncertain whether oral propranolol changes adverse events experienced at short or long term ‐ general adverse… compared with topical timolol (very low certainty).

1 finding from 1 review

Oral propranolol vs placebo

Adverse events experienced at short or long term ‐ Serious adverse events 24 weeks' · infantile haemangiomas (strawberry birthmarks) of the skin

Oral propranolol showed no clear difference in adverse events experienced at short or long term ‐ Serious adverse… compared with placebo (low certainty).

1 finding from 1 review

Lay health worker‐ vs specialist‐led care

Adverse events ‐ death from suicide during intervention (RR > 1 denotes greater risk)Â · people with severe mental disorders

It is very uncertain whether lay health worker‐ changes adverse events ‐ death from suicide during intervention (RR > 1… compared with specialist‐led care (very low certainty).

1 finding from 1 review

Fractional laser vs combined chemical peeling plus needling

Participant‐assessed adverse events (short‐term) N of participants with adverse events · people with acne scars

It is very uncertain whether fractional laser changes participant‐assessed adverse events (short‐term) N of participants… compared with combined chemical peeling plus needling (very low certainty).

1 finding from 1 review

Chemical peeling vs placebo or no treatment

Serious or severe adverse events N of participants with positive severe adverse events · people with acne scars

It is very uncertain whether chemical peeling changes serious or severe adverse events N of participants with positive… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Chemical peeling vs combined chemical peeling plus any active intervention

Participant‐assessed adverse events (short‐term) N of participants with adverse events · people with acne scars

It is very uncertain whether chemical peeling changes participant‐assessed adverse events (short‐term) N of participants… compared with combined chemical peeling plus any active intervention (very low certainty).

1 finding from 1 review