Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,041 questions · 1,056 findings · 283 reviews

No studies found 346 · 32.8%GRADE not reported 111 · 10.5%Very low 326 · 30.9%Low 195 · 18.5%Moderate 66 · 6.3%High 12 · 1.1%

Alarm vs desmopressin

Proportion of children with adverse events · children with nocturnal enuresis

Alarm probably leads to lower proportion of children with adverse events compared with desmopressin (moderate certainty).

1 finding from 1 review

Oral cyclophosphamide vs prednisone or placebo

Adverse events: hypertension with seizures · idiopathic steroid‐resistant nephrotic syndrome in children

It is very uncertain whether oral cyclophosphamide changes adverse events: hypertension with seizures compared with prednisone or placebo (very low certainty).

1 finding from 1 review

Surgical interventions (exploration and decompression / external neurolysis, internal neurolysis, neurorrhaphy / direct repair, neuroma excision, anastomosis, autologous or allograft nerve grafting or tubulization) vs conservative interventions

Participants with adverse events at 1 year · adults with acute acromioclavicular dislocation of the shouldera

It is very uncertain whether surgical intervention changes participants with adverse events at 1 year compared with conservative intervention (very low certainty).

1 finding from 1 review

Group B antipsychotic drugs: amisulpiride + needs‐focused intervention vs needs‐focused intervention

Adverse effects: suicidal thoughts (events) · people in the prodromal stage of psychosis

It is very uncertain whether group B antipsychotic drugs: amisulpiride + needs‐focused intervention changes adverse effects: suicidal thoughts (events) compared with needs‐focused intervention (very low certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Adverse events: hypertension · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in adverse events (weeks 0 to 26): hypertension compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs an extended ZDV/3TC/ABC administered to mothers

Infant Grade 3/4 Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in infants with Grade 3/4 Severe Adverse Events compared with an extended ZDV/3TC/ABC administered to mothers (low certainty).

1 finding from 1 review

Mycophenolate sodium + oral steroids vs oral steroids alone

Adverse events: new‐onset glucose intolerance · minimal change disease in adults with nephrotic syndrome

Mycophenolate sodium + oral steroids showed no clear difference in adverse events: new‐onset glucose intolerance compared with oral steroids alone (low certainty).

1 finding from 1 review