Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,228 questions · 1,245 findings · 383 reviews

No studies found 403 · 32.4%GRADE not reported 128 · 10.3%Very low 385 · 30.9%Low 232 · 18.6%Moderate 81 · 6.5%High 16 · 1.3%

L‐ornithine L‐aspartate vs placebo or no intervention

Serious adverse events assessed using ICH‐GCP

It is very uncertain whether L‐ornithine L aspartate changes serious adverse events assessed using ICH‐GCP compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Active stimulation vs Placebo (sham/placebo device)

Adverse events: infection · adults with chronic pain

The review found no eligible studies for this question.

2 findings from 1 review

Rituximab/cyclosporin/prednisolone vs cyclosporin/prednisolone

Adverse effects of antibiotics (skin rash) · idiopathic steroid‐resistant nephrotic syndrome in children

It is very uncertain whether rituximab/cyclosporin/prednisolone changes adverse events: skin rash compared with cyclosporin/prednisolone (very low certainty).

1 finding from 1 review

L‐ornithine L‐aspartate vs placebo or no intervention

Non‐serious adverse events assessed using ICH‐GCP

It is very uncertain whether L‐ornithine L aspartate changes non‐serious adverse events assessed using ICH‐GCP compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Doxepin cream vs oral antihistamine

Somnolence · people with postburn pruritus

It is very uncertain whether doxepin cream changes adverse events (somnolence) compared with oral antihistamine (very low certainty).

1 finding from 1 review

Rituximab/cyclosporin/prednisolone vs cyclosporin/prednisolone

Adverse events: hypotension · idiopathic steroid‐resistant nephrotic syndrome in children

It is very uncertain whether rituximab/cyclosporin/prednisolone changes adverse events: hypotension compared with cyclosporin/prednisolone (very low certainty).

1 finding from 1 review