Oral magnesium pidolate vs placebo or no intervention
Adverse events: diarrhoea and headache · people with sickle cell disease
1 finding from 1 review
- no estimate extracted1 study · 12 participantsModerate
Findings
What do systematic reviews say?
1,228 questions · 1,245 findings · 383 reviews
No studies found 403 · 32.4%GRADE not reported 128 · 10.3%Very low 385 · 30.9%Low 232 · 18.6%Moderate 81 · 6.5%High 16 · 1.3%
Primary‐level worker‐led collaborative care vs usual care
Adverse events ‐ death · adults with common mental disorders
It is very uncertain whether primary‐level worker‐led collaborative care changes adverse events ‐ death compared with usual care (very low certainty).
1 finding from 1 review
- Primary‐level worker interventions for the care of people living with mental disorders and distress in low‐ and… 2021 · Cochrane Headline outcomes onlyRR 0.63 [0.38, 1.06]5 studies · 5300 participantsVery low
Intervention not reported
Serious adverse events · Patients with COVID‐19
1 finding from 1 review
- Interventions for palliative symptom control in COVID‐19 patients 2021 · Cochrane Headline outcomes onlyno estimate extracted0 studies · 0 participantsGRADE not reported
Leflunomide vs methotrexate
Serious adverse events* · adults with renal vasculitis for maintenance therapy
Leflunomide showed no clear difference in serious adverse events* compared with methotrexate (low certainty).
1 finding from 1 review
- RR 11.81 [0.69, 203.68]1 study · 54 participantsLow
Tacrolimus 0.1% vs mometasone furoate ointment
Primary outcome 3: Adverse events · people with moderate to severe chronic relapsing dyshidrotic eczema on hands
1 finding from 1 review
- no estimate extracted1 study · 16 participantsModerate
Corticosteroid creams/ointments: mometasone furoate cream 3 times/week vs 2 times/week
Primary outcome 3: Adverse events · people (all patch‐tested) with hand eczema > 6 months that had cleared upon daily treatment for a maximum of 9 weeks with mometasone…
Corticosteroid creams/ointments: mometasone furoate cream 3 times/week showed no clear difference in primary: adverse events compared with 2 times/week (low certainty).
1 finding from 1 review
- RR 1.76 [0.45, 6.83]1 study · 72 participantsLow
Intervention not reported
Adverse events (number) · people with necrotising pancreatitis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Percutaneous ethanol injection vs no intervention, other ablation methods, or systemic treatment
Serious adverse events and complications · people with liver metastases
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Nicotinamide plus tetracycline vs prednisone
Adverse events at 1 year · bullous pemphigoid
1 finding from 1 review
- no estimate extractedStudies not reportedVery low
Methylprednisolone plus azathioprine vs methylprednisolone plus dapsone
Adverse events at 1 year · bullous pemphigoid
1 finding from 1 review
- no estimate extractedStudies not reportedVery low
Mild clobetasol propionate cream regimen (10 to 30 g/day) vs standard clobetasol propionate cream regimen (40 g/day)
Adverse events at 1 year · bullous pemphigoid
Mild clobetasol propionate cream regimen (10 to 30 g/day) showed no clear difference in adverse events at 1 year compared with standard clobetasol propionate cream regimen (40 g/day) (low certainty).
1 finding from 1 review
- RR 0.94 [0.78, 1.14]1 study · 309 participantsLow
Culturally and literacy adapted audio‐/visual education without personal feedback vs written information on the same topic
Anxiety (adverse effect, post‐intervention) · migrants
1 finding from 1 review
- no estimate extracted1 study · 445 participantsModerate
Urtoxazumab (3.0 mg/kg) vs placebo
Adverse events ‐ serious · paediatric patients with diarrhoea due to Shiga toxin‐producing E. coli
Urtoxazumab (3.0 mg/kg) may leads to lower adverse events ‐ serious compared with placebo (low certainty).
1 finding from 1 review
- Interventions for preventing diarrhoea‐associated haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes onlyno estimate extracted1 study · 71 participantsLow
Urtoxazumab (1.0 mg/kg) vs placebo
Adverse events ‐ serious · paediatric patients with diarrhoea due to Shiga toxin‐producing E. coli
1 finding from 1 review
- Interventions for preventing diarrhoea‐associated haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes onlyno estimate extracted1 study · 74 participantsLow
IV vs oral cyclophosphamide
Adverse events: Vomiting · idiopathic steroid‐resistant nephrotic syndrome in children
It is very uncertain whether IV changes adverse events: vomiting compared with oral cyclophosphamide (very low certainty).
1 finding from 1 review
- Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes onlyRR 2.38 [0.35, 16.17]2 studies · 61 participantsVery low
IV vs oral cyclophosphamide
Alopecia · idiopathic steroid‐resistant nephrotic syndrome in children
IV showed no clear difference in adverse events: alopecia compared with oral cyclophosphamide (low certainty).
1 finding from 1 review
- Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes onlyRR 1.5 [0.27, 8.22]1 study · 50 participantsLow
NSAIDs vs placebo
Serious adverse events ( · adults with sickle cell disease in a vaso‐occlusive crisis
1 finding from 1 review
- Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes onlyno estimate extracted3 studies · 93 participantsVery low
Intervention not reported
Adverse events Length of · and
It is very uncertain whether the intervention changes adverse events Length of (very low certainty).
1 finding from 1 review
- Interventions for preventing falls in older people in care facilities and hospitals 2018 · Cochrane Headline outcomes onlyRR 4.84 [0.24, 98.9]2 studies · 747 participantsVery low
Summary of findings: Additional exercise plus physiotherapy vs usual physiotherapy
Adverse events Length of · and
1 finding from 1 review
- Interventions for preventing falls in older people in care facilities and hospitals 2018 · Cochrane Headline outcomes onlyno estimate extracted1 study · 161 participantsVery low
Summary of findings: Bed alarms vs usual care
Adverse events Length of · and
1 finding from 1 review
- Interventions for preventing falls in older people in care facilities and hospitals 2018 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 27742 participantsVery low