Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

51 questions · 56 findings · 27 reviews

No studies found 2 · 3.6%GRADE not reported 3 · 5.4%Very low 9 · 16.1%Low 19 · 33.9%Moderate 17 · 30.4%High 6 · 10.7%

Intervention not reported

Proportion of participants who experienced operative or postoperative serious adverse events · patients with multiple sclerosis and chronic cerebrospinal venous insufficiency (CCSVI)

The intervention showed no clear difference in proportion of participants who experienced operative or… (moderate certainty).

1 finding from 1 review

Bortezomib vs no bortezomib

Adverse Events: Infections (All) ‐ Bortezomib versus no bortezomib (same background therapy) · All patients with a diagnosis of multiple myeloma

Bortezomib showed no clear difference in adverse Events: Infections (All) ‐ Bortezomib versus no bortezomib… compared with no bortezomib (high certainty).

1 finding from 1 review

Bortezomib vs no bortezomib

Adverse Events: Peripheral Neuropathy ‐ Bortezomib versus no bortezomib (same background therapy) · All patients with a diagnosis of multiple myeloma

Bortezomib may leads to higher adverse Events: Peripheral Neuropathy ‐ Bortezomib versus no… compared with no bortezomib (low certainty).

1 finding from 1 review

Alemtuzumab 24 mg vs interferon beta‐1a

Adverse events, including serious adverse events Assessed by: number of participants with ≥ 1 event · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…

Alemtuzumab 24 mg showed no clear difference in adverse events, including serious adverse events Assessed by: number… compared with interferon beta‐1a (low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…
1 finding from 1 review

Palliative care vs usual care

Adverse effects: at least one serious adverse event · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…

Palliative care showed no clear difference in serious adverse events Assessed by: number of participants… compared with usual care (low certainty).

1 finding from 1 review

Intervention not reported

The proportion of patients who discontinued study drug because of adverse events excluding relapses at two years · Patients with relapsing‐remitting multiple sclerosis

The intervention probably leads to higher the proportion of patients who discontinued study drug because of… (moderate certainty).

1 finding from 1 review

Bortezomib vs no bortezomib

Adverse Events: Infections (All) ‐ Bortezomib versus no bortezomib (different background therapy or other agents) · All patients with a diagnosis of multiple myeloma

Bortezomib may leads to higher adverse Events: Infections (All) ‐ Bortezomib versus no bortezomib… compared with no bortezomib (low certainty).

1 finding from 1 review

Bortezomib vs no bortezomib

Adverse Events: Cardiac Disorders ‐ Bortezomib versus no bortezomib (different background therapy or other agents) · All patients with a diagnosis of multiple myeloma

Bortezomib leads to higher adverse Events: Cardiac Disorders ‐ Bortezomib versus no bortezomib… compared with no bortezomib (high certainty).

1 finding from 1 review

Bortezomib vs no bortezomib

Adverse Events: Peripheral Neuropathy ‐ Bortezomib versus no bortezomib (different background therapy or other agents) · All patients with a diagnosis of multiple myeloma

Bortezomib leads to higher adverse Events: Peripheral Neuropathy ‐ Bortezomib versus no… compared with no bortezomib (high certainty).

1 finding from 1 review