Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

254 questions · 260 findings · 116 reviews

No studies found 72 · 27.7%GRADE not reported 20 · 7.7%Very low 90 · 34.6%Low 47 · 18.1%Moderate 27 · 10.4%High 4 · 1.5%

iMRI image‐guided surgery vs surgery

Adverse events · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

5‐ALA image‐guided surgery vs surgery

Adverse events · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Active exercise regimen vs an immobilisation regimen following surgery

Adverse events requiring (or indicated for) surgery · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa

It is very uncertain whether active exercise regimen changes adverse events requiring (or indicated for) surgery compared with an immobilisation regimen following surgery (very low certainty).

1 finding from 1 review

Place and hold exercise regimen vs controlled passive exercise regimen following surgery

Adverse events requiring (or indicated for) surgery · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa

It is very uncertain whether place and hold exercise regimen changes adverse events requiring (or indicated for) surgery compared with controlled passive exercise regimen following surgery (very low certainty).

1 finding from 1 review

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery

Adverse events (severe) · people with single or solitary brain metastasis

It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (severe) compared with stereotactic radiosurgery (very low certainty).

1 finding from 1 review

Neuronavigation image‐guided surgery vs surgery

Adverse events · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery

Adverse events (moderate) · people with single or solitary brain metastasis

It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (moderate) compared with stereotactic radiosurgery (very low certainty).

1 finding from 1 review

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery plus WBRT

Adverse events (moderate) · people with single or solitary brain metastasis

It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (moderate) compared with stereotactic radiosurgery plus WBRT (very low certainty).

1 finding from 1 review

Percutaneous surgery vs open surgery

Adverse events (infection, partial loss of movement, tendon or pulley injury, oedema or inflammation or hematoma, adherence) · patients with trigger finger

It is very uncertain whether percutaneous surgery changes adverse events (infection, partial loss of movement, tendon or… compared with open surgery (very low certainty).

1 finding from 1 review

Open surgery by transverse incision of the skin in the distal palmar crease vs open surgery

Adverse events Not measured · patients with trigger finger

The review found no eligible studies for this question.

3 findings from 1 review

Open surgery vs steroid injection plus hyaluronic acid injection guided by ultrasound

Adverse events (partial loss of movement, algodystrophic syndrome) · patients with trigger finger

It is very uncertain whether open surgery changes adverse events (partial loss of movement, algodystrophic syndrome) compared with steroid injection plus hyaluronic acid injection guided by ultrasound (very low certainty).

1 finding from 1 review

Open surgery vs steroid injection

Adverse events (infection, tendon or pulley injury, flare, cutaneous discomfort, fat necrosis) · patients with trigger finger

Open surgery showed no clear difference in adverse events (infection, tendon or pulley injury, flare, cutaneous… compared with steroid injection (low certainty).

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs alternative haemostatic agents

Serious adverse events measured by plasma transfusion‐related complications within 24 hours № of participants: 21 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether prophylactic plasma transfusion before surgery/invasive procedures changes serious adverse events measured by plasma transfusion‐related… compared with alternative haemostatic agents (very low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Serious adverse events measured by surgery or procedure‐related complications within 30 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Percutaneous surgery vs steroid injection

Adverse events (infection, partial loss of movement, tendon or −0 injury, dysaesthesia, and skin atrophy or hypopigmentation) · patients with trigger finger

It is very uncertain whether percutaneous surgery changes adverse events (infection, partial loss of movement, tendon or −0… compared with steroid injection (very low certainty).

1 finding from 1 review