Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

85 questions · 85 findings · 26 reviews

No studies found 24 · 28.2%GRADE not reported 5 · 5.9%Very low 29 · 34.1%Low 18 · 21.2%Moderate 5 · 5.9%High 4 · 4.7%

Rifapentine plus isoniazid weekly vs isoniazid

Treatment‐limiting adverse events · HIV‐negative people at risk of TB infection1

Rifapentine plus isoniazid weekly probably leads to higher treatment‐limiting adverse events compared with isoniazid daily (moderate certainty).

1 finding from 1 review

Bronchial thermoplasty vs active control

Participants admitted to hospital because of respiratory adverse events (post‐treatment period) · adults with asthma

Bronchial thermoplasty showed no clear difference in participants admitted to hospital because of respiratory adverse… compared with any active control (moderate certainty).

1 finding from 1 review

Conventional occlusion vs atropine penalization

Adverse events (reported occurrence of: mild reduction in the visual acuity of the sound eye not requiring treatment; light sensitivity; skin, lid, or conjunctival irritation) Assessed at different time points (17 weeks or 2 years). · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
1 finding from 1 review

Three infusions of natalizumab (300 mg) and two infusions of infliximab (5 mg/kg) vs placebo and two infusions of infliximab

Adverse events up to week 10 · Participants with active Crohn's disease despite current treatment with infliximab

Three infusions of natalizumab (300 mg) and two infusions of… showed no clear difference in adverse events up to week 10 compared with placebo and two infusions of infliximab (moderate certainty).

1 finding from 1 review