Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

419 questions · 420 findings · 128 reviews

No studies found 71 · 16.9%GRADE not reported 69 · 16.4%Very low 96 · 22.9%Low 116 · 27.6%Moderate 63 · 15%High 5 · 1.2%

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Toxicity (adverse events probably due to drug) · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole,… showed no clear difference in toxicity (adverse events probably due to drug) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs Antifungal drugs not absorbed from GI tract

Toxicity (adverse events probably due to drug) · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract showed no clear difference in toxicity (adverse events probably due to drug) compared with antifungal drugs not absorbed from GI tract; GRADE not reported.

1 finding from 1 review

Intervention not reported

Adverse events Adverse event episodes (n) reported · patients with treating osteoarthritis

The intervention probably leads to lower adverse events Adverse event episodes (n) reported (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events Adverse event episodes (n) reported · patients with treating osteoarthritis

The intervention showed no clear difference in adverse events Adverse event episodes (n) reported (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events (number of adverse events/person/year) · adults (> 18 years of age) with either COPD or recurrent acute exacerbations of chronic bronchitis

The intervention showed no clear difference in adverse events (number of adverse events/person/year) (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events Participants (n) reported adverse events · patients with treating osteoarthritis

The intervention showed no clear difference in adverse events Participants (n) reported adverse events (moderate certainty).

1 finding from 1 review

Boswellia serrata vs valdecoxib

Adverse events Participants (n) reported adverse events · patients with treating osteoarthritis

It is very uncertain whether boswellia serrata changes adverse events Participants (n) reported adverse events compared with valdecoxib (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events Participants (n) reported adverse events · patients with osteoarthritis

The intervention showed no clear difference in adverse events Participants (n) reported adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events Participants (n) reported adverse events · patients with osteoarthritis

The intervention showed no clear difference in adverse events Participants (n) reported adverse events (moderate certainty).

1 finding from 1 review

Macrolide+tetracycline vs macrolides

All‐cause serious adverse events 60 weeks (end of study) · patients with chronic obstructive pulmonary disease

It is very uncertain whether macrolide+tetracycline changes all‐cause serious adverse events 60 weeks (end of study) compared with macrolide (very low certainty).

1 finding from 1 review