Findings

What do systematic reviews say?

1,514 questions · 1,543 findings · 649 reviews

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No studies found 224 · 14.5%GRADE not reported 105 · 6.8%Very low 383 · 24.8%Low 447 · 29%Moderate 293 · 19%High 91 · 5.9%

Bromhexine vs placebo

Adverse events · people with bronchiectasis

Bromhexine showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Mucolytics for bronchiectasis 2014 · Cochrane Headline outcomes only
OR 2.93 [0.12, 73.97]
1 study · 88 participants
Low

Summary of findings ‐ Inhaled mannitol vs placebo

Adverse events · people with bronchiectasis

Inhaled mannitol showed no clear difference in adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
OR 0.96 [0.61, 1.51]
2 studies · 804 participants
Moderate

Intranasal neostigmine vs placebo

Adverse events · people with myasthenia gravis

1 finding from 1 review

Acetylcholinesterase inhibitor treatment for myasthenia gravis 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Vedolizumab vs placebo

Adverse events · Patients with moderately to severely active ulcerative colitis

Vedolizumab showed no clear difference in adverse events compared with placebo (high certainty).

1 finding from 1 review

Vedolizumab for induction and maintenance of remission in ulcerative colitis 2014 · Cochrane Headline outcomes only
RR 0.99 [0.93, 1.07]
2 studies · 941 participants
High

Oral corticosteroids vs placebo or NSAID

Adverse events · patients with acute sinusitis

1 finding from 1 review

Systemic corticosteroids for acute sinusitis 2014 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1193 participants
Moderate

Pulsed electromagnetic field therapy (PEMF) vs placebo

Adverse events · patients with adhesive capsulitis (frozen shoulder)

The review found no eligible studies for this question.

1 finding from 1 review

Electrotherapy modalities for adhesive capsulitis (frozen shoulder) 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low‐level laser therapy vs placebo

Adverse events · patients with adhesive capsulitis (frozen shoulder)

1 finding from 1 review

Electrotherapy modalities for adhesive capsulitis (frozen shoulder) 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Low

Low‐level laser therapy vs Placebo (sham) laser therapy

Adverse events · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes
SoF row 'Adverse events': This outcome was not reported in the included studies.
0 studies
No studies found

Electrostimulation (device) vs Placebo (sham/placebo device)

Adverse events · Adults with dry mouth due to Sjogren's Syndrome

1 finding from 1 review

Interventions for the management of dry mouth: non‐pharmacological interventions 2013 · Cochrane All outcomes
Wong 2003 stated 'no adverse effects were caused by Codetron'; Steller 1988 and Talal 1992 did not mention whether adverse effects occurred
Studies not reported
GRADE not reported

Oral NSAIDs vs placebo

Adverse events · Adults with lateral elbow pain

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 292 participants
GRADE not reported

Topical NSAIDs vs placebo

Adverse events · Adults with lateral elbow pain

Topical NSAIDs showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults 2013 · Cochrane Headline outcomes only
RR 1.55 [0.2, 12.14]
3 studies · 153 participants
Low

Herbal preparations vs placebo

Adverse events · women with uterine fibroids

The review found no eligible studies for this question.

1 finding from 1 review

Herbal preparations for uterine fibroids 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin C vs placebo

Adverse events · adults and children with exercise‐induced bronchoconstriction/asthma

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin C for asthma and exercise‐induced bronchoconstriction 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin C vs placebo

Adverse events · people with asthma

1 finding from 1 review

Vitamin C for asthma and exercise‐induced bronchoconstriction 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 41 participants
Very low

Acupuncture vs sham

Adverse events · Adults with dry mouth due to radiotherapy (head and neck cancer) or Sjogren's Syndrome

1 finding from 1 review

Interventions for the management of dry mouth: non‐pharmacological interventions 2013 · Cochrane All outcomes
Acupuncture was associated with more adverse effects (tiny bruises and tiredness, mild and temporary); List 1998 noted significant eye discomfort; Pfister 2010 reported temporary increases in pain, minor bruising or…
4 studies
GRADE not reported

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Adverse events · Adults undergoing dental implant placement

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in adverse events compared with no antibiotics or placebo; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes
3 to 5 months
RR 1.0 [0.06, 15.85]
6 studies · 1162 participants
GRADE not reported

Antipyretic drugs vs no antipyretic drug or placebo

Adverse events · patients with fever in malaria

The review found no eligible studies for this question.

1 finding from 1 review

Antipyretic measures for treating fever in malaria 2012 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Black cohosh vs placebo

Adverse events · patients with menopausal symptoms

Black cohosh showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Black cohosh (Cimicifuga spp.) for menopausal symptoms 2012 · Cochrane Headline outcomes only
RR 1.04 [0.82, 1.32]
2 studies · 344 participants
Low

3,4‐Diaminopyridine vs placebo

Adverse events · participants with Lambert‐Eaton myasthenic syndrome

1 finding from 1 review

Treatment for Lambert‐Eaton myasthenic syndrome 2011 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 42 participants
High

Oral ondansetron (weight based) vs placebo

Adverse events · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

1 finding from 1 review

Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents 2011 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 465 participants
GRADE not reported