Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

254 questions · 260 findings · 116 reviews

No studies found 72 · 27.7%GRADE not reported 20 · 7.7%Very low 90 · 34.6%Low 47 · 18.1%Moderate 27 · 10.4%High 4 · 1.5%

Laparoscopic fundoplication vs medical management

Serious adverse events · Patients with gastro‐oesophageal reflux disease (GORD) in adults

It is very uncertain whether laparoscopic fundoplication changes serious adverse events compared with medical management (very low certainty).

1 finding from 1 review

Summary of findings ‐ Erector spinae plane block vs serratus anterior plane block

Rates of block‐related adverse events · adults undergoing surgery with general anaesthesia

Summary of findings ‐ Erector spinae plane block showed no clear difference in rates of block‐related adverse events compared with serratus anterior plane block (low certainty).

1 finding from 1 review

Summary of findings ‐ Erector spinae plane block vs intercostal nerve block

Rates of block‐related adverse events · adults undergoing surgery with general anaesthesia

It is very uncertain whether summary of findings ‐ Erector spinae plane block changes rates of block‐related adverse events compared with intercostal nerve block (very low certainty).

1 finding from 1 review

Summary of findings ‐ Erector spinae plane block vs paravertebral block

Rates of block‐related adverse events · adults undergoing surgery with general anaesthesia

Summary of findings ‐ Erector spinae plane block probably leads to lower rates of block‐related adverse events compared with paravertebral block (moderate certainty).

1 finding from 1 review

Summary of findings ‐ Erector spinae plane block vs transversus abdominis plane block

Rates of block‐related adverse events · adults undergoing surgery with general anaesthesia

Summary of findings ‐ Erector spinae plane block showed no clear difference in rates of block‐related adverse events compared with transversus abdominis plane block (low certainty).

1 finding from 1 review

Primary comparison for continuous passive motion (CPM) vs no CPM

Adverse events (a count of reported harms or adverse events/experiences over life of study/ · hospitalised patients who have undergone knee replacement surgery

Primary comparison for continuous passive motion (CPM) showed no clear difference in adverse events Counts of adverse events compared with no CPM (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events (total): · adults aged ≥ 18 years with a diagnosis of glenohumeral osteoarthritis who have not responded to non‐operative treatments

It is very uncertain whether the intervention changes adverse events (total): (very low certainty).

1 finding from 1 review

Oral paracetamol vs placebo

Patients with one or more adverse events · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local…

Paracetamol (single oral dose, any dose or formulation; subgroups up… showed no clear difference in patients with one or more adverse events compared with placebo; GRADE not reported.

1 finding from 1 review