Adverse effects · Children with otitis media with effusion
Antibiotics may leads to higher adverse effects compared with placebo, no treatment or therapy of unproven effectiveness (low certainty).
1 finding from 1 review
Adverse effects · Patients with idiopathic acute vestibular dysfunction (vestibular neuritis)
1 finding from 1 review
Other adverse effects · people with olfactory dysfunction for less than 4 weeks following COVID‐19 infection
1 finding from 1 review
Other adverse effects · participants with olfactory dysfunction following COVID‐19 for ≤ 15 days
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Serious adverse effects · participants with olfactory dysfunction following COVID‐19 for ≤ 15 days
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects: headache · chronic rhinosinusitis
It is very uncertain whether topical antifungal changes adverse effects ‐ headache compared with placebo/no treatment (very low certainty).
1 finding from 1 review
RR 1.26 [0.6, 2.63]
Studies not reported
Very low
Adverse effects ‐ epistaxis · chronic rhinosinusitis
Topical antifungal showed no clear difference in adverse effects ‐ epistaxis compared with placebo/no treatment (low certainty).
1 finding from 1 review
RR 0.97 [0.14, 6.63]
Studies not reported
Low
Adverse effects: serious or other · adults with nasal haemorrhage (epistaxis)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Other adverse effects (yes or no) · patients with subjective idiopathic tinnitus
2 findings from 1 review
Other adverse effects (yes or no) · patients with subjective idiopathic tinnitus
1 finding from 1 review
Adverse effects ‐ hepatic toxicity · chronic rhinosinusitis
Systemic antifungal showed no clear difference in adverse effects ‐ hepatic toxicity compared with placebo/no treatment (low certainty).
1 finding from 1 review
RR 3.35 [0.14, 78.6]
Studies not reported
Low
Other adverse effects: local irritation · chronic rhinosinusitis
Topical antifungal showed no clear difference in adverse effects ‐ local irritation compared with placebo/no treatment (low certainty).
1 finding from 1 review
RR 2.29 [0.61, 8.62]
Studies not reported
Low
Allergic adverse events · chronic rhinosinusitis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Significant adverse events · patients with subjective idiopathic tinnitus
1 finding from 1 review
Significant adverse events · patients with subjective idiopathic tinnitus
2 findings from 1 review
Gastrointestinal adverse events · chronic rhinosinusitis
Systemic antifungal showed no clear difference in adverse effects ‐ gastrointestinal disturbances compared with placebo/no treatment (low certainty).
1 finding from 1 review
RR 0.37 [0.04, 3.36]
Studies not reported
Low
Adverse event: systemic corticosteroid side effects · children aged 6 months to 12 years with otitis media with effusion (OME)
It is very uncertain whether topical (intranasal) steroids changes adverse event: systemic corticosteroid side effects compared with placebo (very low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Adverse event: systemic corticosteroid side effects · children aged 6 months to 12 years with otitis media with effusion (OME)
It is very uncertain whether oral steroids changes adverse event: systemic corticosteroid side effects compared with placebo (very low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Serious adverse effects (bleeding or seizures) · adults with tinnitus
1 finding from 1 review
Proportion of patients with adverse effects№ of participants: 819(12 RCTs) · patients with symptoms of vertigo
Betahistine showed no clear difference in proportion of patients with adverse effects№ of participants: 819(12… compared with placebo (low certainty).
1 finding from 1 review