Cochrane · systematic review · CD009163
Antibiotics for otitis media with effusion in children
Venekamp, RP, Burton, MJ, van Dongen, TMA, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
ENTAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 83.3%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antibiotics compared to placebo, no treatment or therapy of unproven effectiveness for otitis media with effusion in children
Population: children with otitis media with effusion
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete resolution of OME at 2 to 3 months Antibiotics vs placebo, no treatment or therapy of unproven effectiveness | RR 2 [1.58, 2.53] | 6 studies · 484 participants | Moderate Downgraded: risk of bias |
Adverse effects Antibiotics vs placebo, no treatment or therapy of unproven effectiveness | RR 2.15 [1.29, 3.6] | 5 studies · 742 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Complete resolution of OME at 2 to 4 weeks Antibiotics vs placebo, no treatment or therapy of unproven effectiveness | RR 1.98 [1.47, 2.67] | 14 studies · 2091 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Complete resolution of OME at more than 6 months Antibiotics vs placebo, no treatment or therapy of unproven effectiveness | RR 1.75 [1.41, 2.18] | 5 studies · 606 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Insertion of ventilation tubes Antibiotics vs placebo, no treatment or therapy of unproven effectiveness | RR 0.9 [0.46, 1.78] | 2 studies · 121 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Tympanic membrane sequelae Antibiotics vs placebo, no treatment or therapy of unproven effectiveness | RR 0.42 [0.18, 1.01] | 1 study · 103 participants | Low Downgraded: risk of bias, imprecision, inconsistency |