Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

14 questions · 14 findings · 9 reviews

No studies found 3 · 21.4%GRADE not reported 3 · 21.4%Very low 5 · 35.7%Low 3 · 21.4%Moderate 0 · 0%High 0 · 0%

Antibiotic prophylaxis before dental procedure vs placebo or no prophylaxis

Adverse effects of antibiotics · Adults or children at increased risk of bacterial endocarditis (pre-existing cardiac condition) undergoing an invasive dental procedure

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic prophylaxis vs no treatment or placebo

Adverse effects of antibiotics (skin rash) · Women who had normal vaginal births

It is very uncertain whether routine antibiotic prophylaxis changes adverse effects of antibiotics (skin rash) compared with no treatment or placebo (very low certainty).

1 finding from 1 review

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Adverse effects · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Total adverse effects · women having elective abdominal hysterectomy

It is very uncertain whether antibiotics changes total adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Nausea and vomiting · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in adverse effects: incidences of nausea and vomiting compared with continuation (low certainty).

1 finding from 1 review

Hyperbaric oxygen therapy (HBO) following extractions vs penicillin G

Adverse effects · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
1 finding from 1 review

Intervention not reported

Total adverse effects · women having elective vaginal hysterectomy
1 finding from 1 review

Intervention not reported

Total adverse effects · women having elective abdominal hysterectomy

The review found no eligible studies for this question.

1 finding from 1 review