Cochrane · systematic review · CD004637
Antibiotic prophylaxis for elective hysterectomy
Ayeleke, RO, Mourad, SM, Marjoribanks, J, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
17
current version
GRADE rated
15
No studies
2
Included studies
NR
No studies 2 · 11.8%Ungraded 0 · 0%Very low 6 · 35.3%Low 2 · 11.8%Moderate 7 · 41.2%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antibiotics compared with placebo for prophylaxis in elective vaginal hysterectomy
Population: women having elective vaginal hysterectomy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total postoperative infections ‐ early and late Antibiotics vs placebo | RR 0.28 [0.19, 0.4] | 4 studies · 293 participants | Low Downgraded: risk of bias, inconsistency |
Urinary tract infection Antibiotics vs placebo | RR 0.58 [0.43, 0.77] | 8 studies · 1473 participants | Moderate Downgraded: risk of bias |
Pelvic infection Antibiotics vs placebo | RR 0.28 [0.2, 0.39] | 11 studies · 1693 participants | Moderate Downgraded: risk of bias, inconsistency |
Other serious infections Antibiotics vs placebo | RR 0.2 [0.01, 4.1] | 1 study · 146 participants | Very low Downgraded: risk of bias, imprecision |
Postoperative fever Antibiotics vs placebo | RR 0.43 [0.34, 0.54] | 9 studies · 1562 participants | Moderate Downgraded: risk of bias |
Total adverse effects ‐ not reported Antibiotics vs placebo | no estimate extracted | NR | No studies |
Antibiotics compared with placebo for prophylaxis in elective abdominal hysterectomy
Population: women having elective abdominal hysterectomy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total postoperative infections ‐ early and late Antibiotics vs placebo | RR 0.38 [0.21, 0.67] | 1 study · 158 participants | Low Downgraded: risk of bias, imprecision |
Abdominal wound infection Antibiotics vs placebo | RR 0.51 [0.36, 0.73] | 11 studies · 2247 participants | Moderate Downgraded: risk of bias |
Urinary tract infection Antibiotics vs placebo | RR 0.41 [0.31, 0.53] | 11 studies · 2705 participants | Moderate Downgraded: risk of bias |
Pelvic infection Antibiotics vs placebo | RR 0.5 [0.35, 0.71] | 11 studies · 1883 participants | Moderate Downgraded: risk of bias |
Other serious infections Antibiotics vs placebo | RR 0.44 [0.12, 1.69] | 2 studies · 476 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Postoperative fever Antibiotics vs placebo | RR 0.59 [0.5, 0.7] | 11 studies · 2394 participants | Moderate Downgraded: risk of bias |
Total adverse effects Antibiotics vs placebo | RR 1.8 [0.62, 5.18] | 2 studies · 430 participants | Very low Downgraded: risk of bias, imprecision |
Head‐to‐head comparisons of antibiotics for prophylaxis in elective vaginal hysterectomy
Population: women having elective vaginal hysterectomy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total postoperative infections ‐ early and late Urinary tract infection Pelvic infection Other serious infections Postoperative fever | no estimate extracted | 2 studies · 470 participants | Very low Downgraded: risk of bias, imprecision |
Total adverse effects | no estimate extracted | 2 studies · 451 participants | Very low Downgraded: risk of bias, imprecision |
Head‐to‐head comparisons of antibiotics for prophylaxis in elective abdominal hysterectomy
Population: women having elective abdominal hysterectomy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total postoperative infections ‐ early and late Abdominal wound infection Urinary tract infection Pelvic infection Other serious infections Postoperative fever | no estimate extracted | 1 study · 220 participants | Very low Downgraded: risk of bias, imprecision |
Total adverse effects | no estimate extracted | NR | No studies |