What do systematic reviews say?

Amitriptyline vs nomifensine

• Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Venlafaxine vs no treatment

• Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Sertraline vs cognitive behavioural therapy

• Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 118 participants
  Low

Intervention not reported

• Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  88 participants
  Low

Paroxetine vs doxepin

• Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 67 participants
  Moderate

Pneumococcal conjugate vaccine vs control vaccine

The review found no eligible studies for this question.

• Pneumococcal conjugate vaccines for preventing acute otitis media in children 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

PREFRONTAL TBS TMS vs SHAM TMS

• Transcranial magnetic stimulation (TMS) for schizophrenia 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 27 participants
  Low

Cessation of water fluoridation (fluoride removed from the water supply) vs Continued fluoridated water

The review found no eligible studies for this question.

• Water fluoridation for the prevention of dental caries 2015 · Cochrane All outcomes
  No evidence to determine whether cessation of a water fluoridation programme is associated with any harms.
  0 studies
  No studies found

Intervention not reported

• Mobile phone messaging for preventive health care 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1705 participants
  Moderate

Intervention not reported

• Home‐based child development interventions for preschool children from socially disadvantaged families 2011 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Prophylactic aciclovir (oral or intravenous) vs placebo

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  Adverse effects were reported in nine trials. Diagnosis was by evaluation of clinical signs and symptoms (e.g. rash, neurological impairment) and by laboratory tests including renal and hepatic function. None of the…
  9 studies
  GRADE not reported

Antidepressants (trazodone 200 mg/day) vs placebo

It is very uncertain whether antidepressants (trazodone 200 mg/day) changes adverse effects: dizziness compared with placebo (very low certainty).

• Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes

  short-term (up to 3 months)
  RR 11.61 [1.66, 81.04]
  1 study · 37 participants
  Very low

Antidepressants (trazodone 200 mg/day) vs placebo

It is very uncertain whether antidepressants (trazodone 200 mg/day) changes adverse effects: dry mouth compared with placebo (very low certainty).

• Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes

  short-term (up to 3 months)
  RR 3.17 [0.36, 27.72]
  1 study · 37 participants
  Very low

Acupuncture or acupressure plus analgesia vs analgesia

It is very uncertain whether acupuncture or acupressure plus analgesia changes adverse effects (pruritus) compared with analgesia (very low certainty).

• Complementary and alternative therapies for post‐caesarean pain 2020 · Cochrane Headline outcomes only
  RR 0.5 [0.08, 3.29]
  1 study · 60 participants
  Very low

Brexpiprazole vs antidepressive agents

Brexpiprazole probably leads to higher adverse effects: akathisia (followed up until the end of the longest compared with antidepressive agents (moderate certainty).

• Brexpiprazole versus placebo or other antidepressive agents for treating depression 2023 · Cochrane Headline outcomes only
  OR 2.95 [2.06, 4.21]
  7 studies · 3358 participants
  Moderate

Brexpiprazole vs antidepressive agents

Brexpiprazole probably leads to higher adverse effects: weight gain (followed up until the end of the longest compared with antidepressive agents (moderate certainty).

• Brexpiprazole versus placebo or other antidepressive agents for treating depression 2023 · Cochrane Headline outcomes only
  OR 3.14 [2.19, 4.49]
  9 studies · 3424 participants
  Moderate

Antidepressants (trazodone 200 mg/day) vs placebo

It is very uncertain whether antidepressants (trazodone 200 mg/day) changes adverse effects: drowsiness compared with placebo (very low certainty).

• Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes

  short-term (up to 3 months)
  RR 4.75 [1.18, 19.07]
  1 study · 37 participants
  Very low

PREFRONTAL TBS TMS vs SHAM TMS

PREFRONTAL TBS TMS showed no clear difference in adverse effects: Leaving the study early compared with SHAM TMS (low certainty).

• Transcranial magnetic stimulation (TMS) for schizophrenia 2015 · Cochrane Headline outcomes only
  RR 0.36 [0.07, 1.74]
  2 studies · 76 participants
  Low

Antidepressants vs a combination of medications

The review found no eligible studies for this question.

• Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Interferon vs placebo

Interferon probably leads to higher adverse effects during use of the preventative intervention (fever)… compared with placebo (moderate certainty).

• Interventions for prevention of herpes simplex labialis (cold sores on the lips) 2015 · Cochrane Headline outcomes only
  RR 2.45 [1.26, 4.78]
  1 study · 32 participants
  Moderate