Cochrane · systematic review · CD001480
Pneumococcal conjugate vaccines for preventing acute otitis media in children
de Sévaux, JLH, Venekamp, RP, Lutje, V, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 2 · 28.6%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 3 versionsPneumococcal conjugate vaccine versus control vaccine for preventing acute otitis media in children
Population: infants (predominantly < 6 months of age) and older children (aged 1 to 7 years)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
CRM197‐PCV7in low‐risk infants Pneumococcal conjugate vaccine vs control vaccine | 6 | 2 studies · 39530 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
CRM197‐PCV7in high‐risk infants Pneumococcal conjugate vaccine vs control vaccine | no estimate extracted | 1 study · 944 participants | Low Downgraded: risk of bias, imprecision, indirectness |
OMPC‐PCV7in low‐risk infants Pneumococcal conjugate vaccine vs control vaccine | no estimate extracted | 1 study · 1666 participants | Low Downgraded: risk of bias, imprecision, indirectness |
PHiD‐CV10in low‐risk infants Pneumococcal conjugate vaccine vs control vaccine | 6 | 2 studies · 12454 participants | Low Downgraded: risk of bias, imprecision, indirectness |
PHiD‐CV11in low‐risk infants Pneumococcal conjugate vaccine vs control vaccine | 34 | 1 study · 4968 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Adverse effects Pneumococcal conjugate vaccine vs control vaccine | no estimate extracted | NR | No studies |
CRM197‐PCV7in low‐risk infants OMPC‐PCV7in low‐risk infants PHiD‐PC10 and PHiD‐PC11 in low‐risk infants CRM197‐PCV7/9 and CRM197‐PCV7 plus TIVin older children Pneumococcal conjugate vaccine vs control vaccine | no estimate extracted | 9 studies · 77389 participants | High |