Cochrane · systematic review · CD001480
Pneumococcal conjugate vaccines for preventing acute otitis media in children
de Sévaux, JLH, Venekamp, RP, Lutje, V, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 2 · 28.6%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyPneumococcal conjugate vaccine versus control vaccine for preventing acute otitis media in children
Population: infants (predominantly < 6 months of age) and older children (aged 1 to 7 years)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
CRM197‐PCV7in low‐risk infants Pneumococcal conjugate vaccine vs control vaccine | 6 | 2 studies · 39530 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
CRM197‐PCV7in high‐risk infants Pneumococcal conjugate vaccine vs control vaccine | no estimate extracted | 1 study · 944 participants | Low Downgraded: risk of bias, imprecision, indirectness |
OMPC‐PCV7in low‐risk infants Pneumococcal conjugate vaccine vs control vaccine | no estimate extracted | 1 study · 1666 participants | Low Downgraded: risk of bias, imprecision, indirectness |
PHiD‐CV10in low‐risk infants Pneumococcal conjugate vaccine vs control vaccine | 6 | 2 studies · 12454 participants | Low Downgraded: risk of bias, imprecision, indirectness |
PHiD‐CV11in low‐risk infants Pneumococcal conjugate vaccine vs control vaccine | 34 | 1 study · 4968 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Adverse effects Pneumococcal conjugate vaccine vs control vaccine | no estimate extracted | NR | No studies |
CRM197‐PCV7in low‐risk infants OMPC‐PCV7in low‐risk infants PHiD‐PC10 and PHiD‐PC11 in low‐risk infants CRM197‐PCV7/9 and CRM197‐PCV7 plus TIVin older children Pneumococcal conjugate vaccine vs control vaccine | no estimate extracted | 9 studies · 77389 participants | High |
Pneumococcal conjugate vaccine versus control vaccine for preventing acute otitis media
Population: infants (predominantly < 6 months of age) and older children (aged 1 to 7 years)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
CRM197‐PCV7in low‐risk infants Pneumococcal conjugate vaccine vs control vaccine | 6 | 2 studies · 39530 participants | High |
CRM197‐PCV7in high‐risk infants Pneumococcal conjugate vaccine vs control vaccine | no estimate extracted | 1 study · 944 participants | Moderate Downgraded: imprecision |
OMPC‐PCV7in low‐risk infants Pneumococcal conjugate vaccine vs control vaccine | no estimate extracted | 1 study · 1666 participants | High |
PHiD‐CV10in low‐risk infants Pneumococcal conjugate vaccine vs control vaccine | 6 | 2 studies · 12454 participants | Moderate Downgraded: risk of bias, imprecision |
PHiD‐CV11in low‐risk infants Pneumococcal conjugate vaccine vs control vaccine | 34 | 1 study · 4968 participants | High |
CRM197‐PCV7in low‐risk infants OMPC‐PCV7in low‐risk infants PHiD‐PC10/11 in low‐risk infants CRM197‐PCV7/9 and CRM197‐PCV7 plus TIVin older children Pneumococcal conjugate vaccine vs control vaccine | no estimate extracted | 9 studies · 77389 participants | High |
Comparison
Population: children aged 12 years or younger and a follow‐up after vaccinations of at least 6 months
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of all‐cause AOM PCV7 administered in early infancy | no estimate extracted | 4 studies · 42140 participants | High |
Frequency of all‐cause AOM PD‐PCV11 administered in early infancy | 34 [21, 44] | 1 study · 4968 participants | Moderate |
Frequency of all‐cause AOM CRM197‐PCV9 administered in healthy toddlers | 17 | 1 study · 264 participants | Moderate |
Frequency of all‐cause AOM PCV7 administered in older children with a known history of AOM | no estimate extracted | 3 studies · 1054 participants | High |
Frequency of pneumococcal AOM PCV7 administered in early infancy | 20 | 2 studies · 1233 participants | High |
Frequency of pneumococcal AOM PD‐PCV11 administered in early infancy | 52 [37, 63] | 1 study · 281 participants | Moderate |