Findings

What do systematic reviews say?

488 questions · 501 findings · 191 reviews

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No studies found 126 · 25.1%GRADE not reported 124 · 24.8%Very low 104 · 20.8%Low 89 · 17.8%Moderate 49 · 9.8%High 9 · 1.8%

Sodium thiosulfate vs no otoprotective intervention

Adverse effects other than ototoxicity (≥ grade 3 according to NCICTCAEv3 criteria) with intravenous platinum · children with cancer treated with platinum‐based therapy

1 finding from 1 review

Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 109 participants
Low

Bathing of the critically ill with chlorhexidine vs bathing with soap and water or non‐antimicrobial washcloths

Adverse effects: skin reactions. Reported as attributable to chlorhexidine or soap and water. Data collected during ICU stay · critically ill patients

1 finding from 1 review

Chlorhexidine bathing of the critically ill for the prevention of hospital‐acquired infection 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 6365 participants
Very low

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Adverse effects (tooth staining/discoloration, oral soft-tissue signs, adverse symptoms such as nausea/vomiting, enamel etching) · Children and adolescents aged 16 years or less

1 finding from 1 review

Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and adolescents 2003 · Cochrane All outcomes
Data on adverse effects (stain score, proportion of children with tooth staining, signs of sensitivity in oral soft tissue, adverse symptoms such as nausea/vomiting, etching of enamel) were reported in only a few…
Studies not reported
GRADE not reported

Fluoride varnish vs placebo or no treatment

Adverse effects / specific side effects (oral allergic reactions, mucosal irritation, adverse symptoms such as nausea, gagging, vomiting) · Children and adolescents aged 16 years or less

1 finding from 1 review

Fluoride varnishes for preventing dental caries in children and adolescents 2013 · Cochrane All outcomes
At least 1 year
Three trials (Salazar 2008; Skold 2005; Weintraub 2006) provided data reporting no adverse effects. There was little information concerning possible adverse effects; no pooled estimate was possible.
3 studies
GRADE not reported

Intervention not reported

Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) · patients with decreasing recall of events during surgery

The review found no eligible studies for this question.

1 finding from 1 review

Anaesthetic interventions for prevention of awareness during surgery 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inactivated influenza vaccine vs placebo

Asthma exacerbation (adverse effects) caused by inactivated influenza vaccine, measured in the first 2 weeks following vaccination ‐ adults given inactivated influenza vaccine · people with asthma

1 finding from 1 review

Vaccines for preventing influenza in people with asthma 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1526 participants
Moderate

Intervention not reported

Adverse effects Defined as deaths, hospitalisations, congenital abnormalities and life‐threatening conditions requiring an immediate hospital visit Assessed at 12 and 18 months of age · children aged 6 to 23 months

The intervention showed no clear difference in adverse effects Defined as deaths, hospitalisations, congenital… (moderate certainty).

1 finding from 1 review

Preventive lipid‐based nutrient supplements given with complementary foods to infants and young children 6 to 23… 2019 · Cochrane Headline outcomes only
RR 0.86 [0.74, 1.01]
3 studies · 3382 participants
Moderate

Inactivated influenza vaccine vs placebo

Asthma exacerbation (adverse effects) caused by inactivated influenza vaccine, measured in the first 2 weeks following vaccination ‐ children (over 3 years of age) given inactivated influenza vaccine · people with asthma

1 finding from 1 review

Vaccines for preventing influenza in people with asthma 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 712 participants
Moderate